gene

BIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1005Connections
3Hypotheses
4Analyses
50Outgoing
50Incoming
0Experiments
7Debates

Summary

Bridging Integrator 1 (BIN1) is the second strongest genetic risk factor for late-onset Alzheimer's disease after APOE4. BIN1 encodes a BAR domain protein involved in membrane dynamics, endocytosis, and cytoskeletal regulation. In neurons, BIN1 modulates tau propagation by regulating endosomal trafficking and tau release via extracellular vesicles. BIN1 also interacts with clathrin and AP-2 to control synaptic vesicle recycling. AD-associated BIN1 variants increase tau pathology spreading and reduce synaptic function. BIN1 is expressed in both neurons and oligodendrocytes, with cell-type-specific roles in disease. BIN1 represents a promising therapeutic target for slowing tau propagation.

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🧬 Gene Info
Gene SymbolBIN1
Full NameBridging Integrator 1
Chromosome2q14.3
Functionis a gene located on chromosome 2q14.
Primary ExpressionCerebral cortex, Hippocampus, White matter, Cerebellum
Molecular Weight70 kDa
Exons20
PathwaysAutophagy, Complement, Endocytosis, proinflammatory activation
UniProt IDO00499
NCBI Gene ID274
Ensembl IDENSG00000136717
OMIM601248
GeneCardsBIN1
Human Protein AtlasBIN1
Associated Diseasesaging, Als, Alzheimer, Alzheimer disease
InteractionsABCA7, Actin, AD, ADAM10, ADAMTS4, AGING
SciDEX HypothesesBIN1 Neuronal Isoform Restoration in Vulnerable Ex
BIN1-Targeted Extracellular Vesicle Trafficking Di
KG Connections1004 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: BIN1 — AlphaFold O00499 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

BIN1 — Bridging Integrator 1

gene · 3043 words

ABIN1 (TNIP1) Gene

gene · 1970 words

BIN1→Endosomal Dysfunction→Tau Pathology→AD Causal Chain

mechanism · 1896 words

ABIN1 Protein

protein · 1054 words

BIN1 Protein

protein · 782 words

Pathway Diagram

graph TD
    BIN1["BIN1"]
    BIN1 -->|"regulates"| phosphorylated_tau["phosphorylated tau"]
    BIN1 -->|"expressed in"| Cancer["Cancer"]
    BIN1 -->|"expressed in"| Tumor["Tumor"]
    BIN1 -->|"expressed in"| Alzheimer["Alzheimer"]
    BIN1 -->|"activates"| Als["Als"]
    BIN1 -->|"expressed in"| Senescence["Senescence"]
    BIN1 -->|"expressed in"| Ms["Ms"]
    BIN1 -->|"activates"| Inflammation["Inflammation"]
    BIN1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CD8["CD8"] -->|"expressed in"| BIN1
    STAT1["STAT1"] -->|"activates"| BIN1

Outgoing (737)

TargetRelationTypeStr
BIN1encodesprotein0.00
ad_genetic_risk_loci:BIN1data_indataset_row0.00
benchmark_ot_ad_answer_key:BIN1data_indataset_row0.00
ds-83b31ef18d49provides_data_fordataset1.00
ds-db4a006ea647provides_data_fordataset1.00

Incoming (268)

SourceRelationTypeStr
BIN1encodesgene0.00
ad_genetic_risk_loci:BIN1data_indataset_row0.00
benchmark_ot_ad_answer_key:BIN1data_indataset_row0.00
ds-f50762b67605data_indataset1.00
ds-83b31ef18d49data_indataset1.00

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
BIN1-dependent trafficking defects determine whether post-Aβ 0.460 neurodegeneration Does tau dendritic missorting persist in
BIN1-Targeted Extracellular Vesicle Trafficking Disruption 0.000 - Tau propagation mechanisms and therapeut
BIN1 Neuronal Isoform Restoration in Vulnerable Excitatory N 0.000 - Cell type vulnerability in Alzheimers Di

Mentioning Analyses (4)

Scientific analyses that reference this entity

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.730

Statistical Fine-Mapping of AD GWAS Loci to Identify Causal Variants

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.380

Variant Annotation and Prioritization of AD Risk Loci

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.862

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 18 hypotheses Top: 0.814

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (7)

Multi-agent debates referencing this entity

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

closed · Rounds: 4 · Score: 0.65 · 2026-04-25

Which non-coding variants at AD GWAS loci have functional evidence for gene regu

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Can Bayesian fine-mapping of the top 25 AD GWAS loci identify credible sets of c

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Does fine-mapping to median 3-variant credible sets provide sufficient resolutio

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Does the BIN1 non-coding variant mechanism provide a druggable target, or is tra

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

Tau propagation mechanisms and therapeutic interception points

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

Related Research

Hypotheses and analyses mentioning BIN1 in their description or question text

No additional research found