BIN1

Understanding Entity Pages

This page aggregates everything SciDEX knows about BIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Bridging Integrator 1 (BIN1) is the second strongest genetic risk factor for late-onset Alzheimer's disease after APOE4. BIN1 encodes a BAR domain protein involved in membrane dynamics, endocytosis, and cytoskeletal regulation. In neurons, BIN1 modulates tau propagation by regulating endosomal trafficking and tau release via extracellular vesicles. BIN1 also interacts with clathrin and AP-2 to control synaptic vesicle recycling. AD-associated BIN1 variants increase tau pathology spreading and reduce synaptic function. BIN1 is expressed in both neurons and oligodendrocytes, with cell-type-specific roles in disease. BIN1 represents a promising therapeutic target for slowing tau propagation.

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graph TD
    BIN1["BIN1"]
    BIN1 -->|"regulates"| phosphorylated_tau["phosphorylated tau"]
    BIN1 -->|"expressed in"| Cancer["Cancer"]
    BIN1 -->|"expressed in"| Tumor["Tumor"]
    BIN1 -->|"expressed in"| Alzheimer["Alzheimer"]
    BIN1 -->|"activates"| Als["Als"]
    BIN1 -->|"expressed in"| Senescence["Senescence"]
    BIN1 -->|"expressed in"| Ms["Ms"]
    BIN1 -->|"activates"| Inflammation["Inflammation"]
    BIN1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CD8["CD8"] -->|"expressed in"| BIN1
    STAT1["STAT1"] -->|"activates"| BIN1