gene

BIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1005Connections

3Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

7Debates

Summary

Bridging Integrator 1 (BIN1) is the second strongest genetic risk factor for late-onset Alzheimer's disease after APOE4. BIN1 encodes a BAR domain protein involved in membrane dynamics, endocytosis, and cytoskeletal regulation. In neurons, BIN1 modulates tau propagation by regulating endosomal trafficking and tau release via extracellular vesicles. BIN1 also interacts with clathrin and AP-2 to control synaptic vesicle recycling. AD-associated BIN1 variants increase tau pathology spreading and reduce synaptic function. BIN1 is expressed in both neurons and oligodendrocytes, with cell-type-specific roles in disease. BIN1 represents a promising therapeutic target for slowing tau propagation.

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🧬 Gene Info

Gene Symbol	BIN1
Full Name	Bridging Integrator 1
Chromosome	2q14.3
Function	is a gene located on chromosome 2q14.
Primary Expression	Cerebral cortex, Hippocampus, White matter, Cerebellum
Molecular Weight	70 kDa
Exons	20
Pathways	Autophagy, Complement, Endocytosis, proinflammatory activation
UniProt ID	O00499
NCBI Gene ID	274
Ensembl ID	ENSG00000136717
OMIM	601248
GeneCards	BIN1
Human Protein Atlas	BIN1
Associated Diseases	aging, Als, Alzheimer, Alzheimer disease
Interactions	ABCA7, Actin, AD, ADAM10, ADAMTS4, AGING
SciDEX Hypotheses	BIN1 Neuronal Isoform Restoration in Vulnerable Ex BIN1-Targeted Extracellular Vesicle Trafficking Di
KG Connections	1004 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BIN1 — AlphaFold O00499 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BIN1["BIN1"]
    BIN1 -->|"regulates"| phosphorylated_tau["phosphorylated tau"]
    BIN1 -->|"expressed in"| Cancer["Cancer"]
    BIN1 -->|"expressed in"| Tumor["Tumor"]
    BIN1 -->|"expressed in"| Alzheimer["Alzheimer"]
    BIN1 -->|"activates"| Als["Als"]
    BIN1 -->|"expressed in"| Senescence["Senescence"]
    BIN1 -->|"expressed in"| Ms["Ms"]
    BIN1 -->|"activates"| Inflammation["Inflammation"]
    BIN1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CD8["CD8"] -->|"expressed in"| BIN1
    STAT1["STAT1"] -->|"activates"| BIN1

Outgoing (737)

Target	Relation	Type	Str
BIN1	encodes	protein	0.00
ad_genetic_risk_loci:BIN1	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:BIN1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
ds-f50762b67605	provides_data_for	dataset	1.00
Alzheimer'S Disease	associated_with	disease	0.95
Sporadic Alzheimer's Disease	downregulates	disease	0.95
Late-Onset Alzheimer'S Disease	risk_factor_for	disease	0.95
Alzheimer's disease	associated_with	disease	0.95
Alzheimer's Disease	associated_with	disease	0.95
Late-Onset Alzheimer's Disease	risk_factor_for	disease	0.95
Neurodegeneration-Related Activation	regulates	process	0.95
Proinflammatory Activation	regulates	process	0.95
Alternate Splicing	involved_in	process	0.90
cellular clearance	mediates	process	0.90
Tau Pathology Propagation	inhibits	process	0.90
AUTOPHAGY	mediates	process	0.90
tau tangles	associated_with	biomarker	0.90
trafficking	regulates	process	0.90
endolysosomal trafficking	mediates	pathway	0.90
Amyloid-Beta Processing	regulates	mechanism	0.90
Endolysosomal Dysfunction	associated_with	mechanism	0.90
Cellular Clearance Mechanisms	regulates	process	0.90
Tau Tangles	associated_with	biomarker	0.88
Amyloid-Beta Plaques	associated_with	biomarker	0.88
tau pathology	associated_with	phenotype	0.88
Endocytosis	associated_with	process	0.85
autophagy	regulates	process	0.85
TAU	associated_with	protein	0.85
Membrane Dynamics	regulates	process	0.85
amyloid-beta plaques	involved_in	biomarker	0.85
Endocytic Flux	inhibits	process	0.85
Tau Pathology	modulates	process	0.85
synaptic function	regulates	process	0.85
cellular clearance	modulates	process	0.85
Ptau	associated_with	biomarker	0.85
Synaptic Transmission	modulates	process	0.85
cytoskeletal dynamics	regulates	process	0.85
CR1	associated_with	gene	0.82
Oligodendrocytes	expressed_in	cell_type	0.80
Neurons	expressed_in	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
cellular homeostasis	associated_with	process	0.80
BDNF/TrkB signaling	inhibits	pathway	0.80
amyloid-beta processing	modulates	process	0.80
Frontal Cortex	expressed_in	cell_type	0.80
Extracellular Tau Seed Uptake	inhibits	process	0.80
oligodendrocytes	expressed_in	cell_type	0.80
synaptic transmission	associated_with	process	0.75

Incoming (268)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:BIN1	data_in	dataset_row	0.00
ad_genetic_risk_loci:BIN1	data_in	dataset_row	0.00
BIN1	encodes	gene	0.00
ds-f50762b67605	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-db4a006ea647	data_in	dataset	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
APOE	associated_with	gene	0.98
AMYLOID	associated_with	gene	0.90
TREM2	interacts_with	gene	0.85
Tau fragment N368	interacts_with	protein	0.80
AMPH1	interacts_with	protein	0.80
AMYOTROPHIC LATERAL SCLEROSIS	activates	disease	0.70
APOE	protects_against	gene	0.70
APP	expressed_in	gene	0.70
BACE1	expressed_in	gene	0.70
ACHE	markers	gene	0.70
AMPK	activates	gene	0.70
APOE	biomarker_for	gene	0.70
APOE	expresses	gene	0.70
ARRB2	causes	gene	0.70
NEUROINFLAMMATION	associated_with	phenotype	0.65
NEURODEGENERATION	inhibits	disease	0.65
HIF1A	degrades	gene	0.65
HIF1A	regulates	gene	0.65
PTK2B	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
ADAM10	interacts_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
AD RISK LOCI	associated_with	gene	0.60
C16ORF95	associated_with	gene	0.60
AD	co_discussed	gene	0.60
AD	regulates	gene	0.60
AD	expresses	gene	0.60
AΒ	expresses	gene	0.60
AD	causes	gene	0.60
AΒ	co_discussed	gene	0.60
ALZHEIMER'S DISEASE	causes	disease	0.60
AND	activates	gene	0.60
VEGFA	associated_with	gene	0.60
CTSH	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ARF6	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ENDOSOME	interacts_with	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
EPILEPSY	interacts_with	gene	0.60
SYNAPSE	regulates	gene	0.60
AD RISK GENES	regulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
BIN1-dependent trafficking defects determine whether post-Aβ	0.460	neurodegeneration	Does tau dendritic missorting persist in
BIN1-Targeted Extracellular Vesicle Trafficking Disruption	0.000	-	Tau propagation mechanisms and therapeut
BIN1 Neuronal Isoform Restoration in Vulnerable Excitatory N	0.000	-	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (7)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning BIN1 in their description or question text

No additional research found

BIN1

Understanding Entity Pages

Summary

Wiki Pages (5)

BIN1 — Bridging Integrator 1

ABIN1 (TNIP1) Gene

BIN1→Endosomal Dysfunction→Tau Pathology→AD Causal Chain

ABIN1 Protein

BIN1 Protein

Pathway Diagram

Outgoing (737)

Incoming (268)

Targeting Hypotheses (3)

Mentioning Analyses (4)

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

Statistical Fine-Mapping of AD GWAS Loci to Identify Causal Variants

Variant Annotation and Prioritization of AD Risk Loci

Tau propagation mechanisms and therapeutic interception points

Experiments (0)

Related Papers (0)

Debates (7)

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

Which non-coding variants at AD GWAS loci have functional evidence for gene regu

Can Bayesian fine-mapping of the top 25 AD GWAS loci identify credible sets of c

Does fine-mapping to median 3-variant credible sets provide sufficient resolutio

Does the BIN1 non-coding variant mechanism provide a druggable target, or is tra

Investigate prion-like spreading of tau pathology through connected brain region

Tau propagation mechanisms and therapeutic interception points

Related Research