gene

BIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1005Connections

3Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

7Debates

Summary

Bridging Integrator 1 (BIN1) is the second strongest genetic risk factor for late-onset Alzheimer's disease after APOE4. BIN1 encodes a BAR domain protein involved in membrane dynamics, endocytosis, and cytoskeletal regulation. In neurons, BIN1 modulates tau propagation by regulating endosomal trafficking and tau release via extracellular vesicles. BIN1 also interacts with clathrin and AP-2 to control synaptic vesicle recycling. AD-associated BIN1 variants increase tau pathology spreading and reduce synaptic function. BIN1 is expressed in both neurons and oligodendrocytes, with cell-type-specific roles in disease. BIN1 represents a promising therapeutic target for slowing tau propagation.

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🧬 Gene Info

Gene Symbol	BIN1
Full Name	Bridging Integrator 1
Chromosome	2q14.3
Function	is a gene located on chromosome 2q14.
Primary Expression	Cerebral cortex, Hippocampus, White matter, Cerebellum
Molecular Weight	70 kDa
Exons	20
Pathways	Autophagy, Complement, Endocytosis, proinflammatory activation
UniProt ID	O00499
NCBI Gene ID	274
Ensembl ID	ENSG00000136717
OMIM	601248
GeneCards	BIN1
Human Protein Atlas	BIN1
Associated Diseases	aging, Als, Alzheimer, Alzheimer disease
Interactions	ABCA7, Actin, AD, ADAM10, ADAMTS4, AGING
SciDEX Hypotheses	BIN1-Targeted Extracellular Vesicle Trafficking Di BIN1 Neuronal Isoform Restoration in Vulnerable Ex
KG Connections	1004 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BIN1 — AlphaFold O00499 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BIN1["BIN1"]
    BIN1 -->|"regulates"| phosphorylated_tau["phosphorylated tau"]
    BIN1 -->|"expressed in"| Cancer["Cancer"]
    BIN1 -->|"expressed in"| Tumor["Tumor"]
    BIN1 -->|"expressed in"| Alzheimer["Alzheimer"]
    BIN1 -->|"activates"| Als["Als"]
    BIN1 -->|"expressed in"| Senescence["Senescence"]
    BIN1 -->|"expressed in"| Ms["Ms"]
    BIN1 -->|"activates"| Inflammation["Inflammation"]
    BIN1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CD8["CD8"] -->|"expressed in"| BIN1
    STAT1["STAT1"] -->|"activates"| BIN1

Outgoing (737)

Target	Relation	Type	Str
ad_genetic_risk_loci:BIN1	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:BIN1	data_in	dataset_row	0.00
BIN1	encodes	protein	0.00
ds-f50762b67605	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Sporadic Alzheimer's Disease	downregulates	disease	0.95
Alzheimer's Disease	associated_with	disease	0.95
Late-Onset Alzheimer'S Disease	risk_factor_for	disease	0.95
Late-Onset Alzheimer's Disease	risk_factor_for	disease	0.95
Neurodegeneration-Related Activation	regulates	process	0.95
Proinflammatory Activation	regulates	process	0.95
Alzheimer'S Disease	associated_with	disease	0.95
Alzheimer's disease	associated_with	disease	0.95
cellular clearance	mediates	process	0.90
Cellular Clearance Mechanisms	regulates	process	0.90
endolysosomal trafficking	mediates	pathway	0.90
Amyloid-Beta Processing	regulates	mechanism	0.90
tau tangles	associated_with	biomarker	0.90
trafficking	regulates	process	0.90
AUTOPHAGY	mediates	process	0.90
Endolysosomal Dysfunction	associated_with	mechanism	0.90
Tau Pathology Propagation	inhibits	process	0.90
Alternate Splicing	involved_in	process	0.90
tau pathology	associated_with	phenotype	0.88
Amyloid-Beta Plaques	associated_with	biomarker	0.88
Tau Tangles	associated_with	biomarker	0.88
amyloid-beta plaques	involved_in	biomarker	0.85
Tau Pathology	modulates	process	0.85
synaptic function	regulates	process	0.85
Endocytic Flux	inhibits	process	0.85
Synaptic Transmission	modulates	process	0.85
TAU	associated_with	protein	0.85
cytoskeletal dynamics	regulates	process	0.85
cellular clearance	modulates	process	0.85
Membrane Dynamics	regulates	process	0.85
Endocytosis	associated_with	process	0.85
autophagy	regulates	process	0.85
Ptau	associated_with	biomarker	0.85
CR1	associated_with	gene	0.82
Neurons	expressed_in	cell_type	0.80
Oligodendrocytes	expressed_in	cell_type	0.80
BDNF/TrkB signaling	inhibits	pathway	0.80
cellular homeostasis	associated_with	process	0.80
Frontal Cortex	expressed_in	cell_type	0.80
oligodendrocytes	expressed_in	cell_type	0.80
Extracellular Tau Seed Uptake	inhibits	process	0.80
amyloid-beta processing	modulates	process	0.80
oxidative stress response	participates_in	pathway	0.80
neuroinflammation	associated_with	process	0.75

Incoming (268)

Source	Relation	Type	Str
BIN1	encodes	gene	0.00
ad_genetic_risk_loci:BIN1	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:BIN1	data_in	dataset_row	0.00
ds-f50762b67605	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ds-db4a006ea647	data_in	dataset	1.00
APOE	associated_with	gene	0.98
AMYLOID	associated_with	gene	0.90
TREM2	interacts_with	gene	0.85
Tau fragment N368	interacts_with	protein	0.80
AMPH1	interacts_with	protein	0.80
APOE	expresses	gene	0.70
APOE	biomarker_for	gene	0.70
BACE1	expressed_in	gene	0.70
APP	expressed_in	gene	0.70
APOE	protects_against	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	activates	disease	0.70
AMPK	activates	gene	0.70
ACHE	markers	gene	0.70
ARRB2	causes	gene	0.70
NEUROINFLAMMATION	associated_with	phenotype	0.65
HIF1A	regulates	gene	0.65
HIF1A	degrades	gene	0.65
NEURODEGENERATION	inhibits	disease	0.65
CASS4	activates	gene	0.60
EPHA1	activates	gene	0.60
CLU	activates	gene	0.60
MS4A6A	associated_with	gene	0.60
CHRNE	associated_with	gene	0.60
ZCWPW1	activates	gene	0.60
FERMT2	activates	gene	0.60
CELF1	activates	gene	0.60
ABCA7	activates	gene	0.60
ADAMTS4	interacts_with	gene	0.60
APP	activates	gene	0.60
BACE1	activates	gene	0.60
BACE1	regulates	gene	0.60
BACE1	associated_with	gene	0.60
AGING	activates	gene	0.60
OLIGODENDROCYTE	associated_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
AD	interacts_with	gene	0.60
AD	protects_against	gene	0.60
AD	inhibits	gene	0.60
TREM2	associated_with	gene	0.60
CASS4	associated_with	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
BIN1-dependent trafficking defects determine whether post-Aβ	0.460	neurodegeneration	Does tau dendritic missorting persist in
BIN1-Targeted Extracellular Vesicle Trafficking Disruption	0.000	-	Tau propagation mechanisms and therapeut
BIN1 Neuronal Isoform Restoration in Vulnerable Excitatory N	0.000	-	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (7)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning BIN1 in their description or question text

No additional research found

BIN1

Understanding Entity Pages

Summary

Wiki Pages (5)

BIN1 — Bridging Integrator 1

ABIN1 (TNIP1) Gene

BIN1→Endosomal Dysfunction→Tau Pathology→AD Causal Chain

ABIN1 Protein

BIN1 Protein

Pathway Diagram

Outgoing (737)

Incoming (268)

Targeting Hypotheses (3)

Mentioning Analyses (4)

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

Statistical Fine-Mapping of AD GWAS Loci to Identify Causal Variants

Variant Annotation and Prioritization of AD Risk Loci

Tau propagation mechanisms and therapeutic interception points

Experiments (0)

Related Papers (0)

Debates (7)

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

Which non-coding variants at AD GWAS loci have functional evidence for gene regu

Can Bayesian fine-mapping of the top 25 AD GWAS loci identify credible sets of c

Does fine-mapping to median 3-variant credible sets provide sufficient resolutio

Does the BIN1 non-coding variant mechanism provide a druggable target, or is tra

Investigate prion-like spreading of tau pathology through connected brain region

Tau propagation mechanisms and therapeutic interception points

Related Research