Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Tau Protein: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Microtubule-associated protein tau (MAPT gene) stabilizes neuronal microtubules and facilitates axonal transport. Tau is normally soluble and intracellular, but hyperphosphorylation causes detachment from microtubules and aggregation into paired helical filaments and neurofibrillary tangles. Tau pathology spreads in a stereotypical pattern (Braak stages I-VI) from the transentorhinal cortex to the hippocampus and neocortex, correlating closely with cognitive decline in Alzheimer disease. Tau aggregates also characterize frontotemporal dementia, progressive supranuclear palsy, and corticobasal degeneration.
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| Gene Symbol | tau_protein |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
| Target | Relation | Type | Str |
|---|---|---|---|
| post_translational_modifications | undergoes | pathway | 0.90 |
| PSP | aggregates_in | disease | 0.90 |
| CBD | aggregates_in | disease | 0.90 |
| phosphatidylserine | interacts_with | lipid | 0.70 |
| membrane_curvature | induces | biophysical_property | 0.70 |
| locus_coeruleus_hippocampus_pathway | propagates_through | pathway | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MAPT | encodes | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Pericyte senescence is sufficient to weaken the BBB even wit | 0.630 | neurodegeneration | Does pericyte senescence drive BBB break |
Scientific analyses that reference this entity
molecular biology | 2026-04-09 | 7 hypotheses Top: 0.455
neurodegeneration | 2026-04-09 | 3 hypotheses Top: 0.455
neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968
neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.732
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.65 · 2026-04-27
closed · Rounds: 4 · Score: 0.71 · 2026-04-27
closed · Rounds: 4 · Score: 0.87 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.54 · 2026-04-27
closed · Rounds: 4 · Score: 0.19 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
Hypotheses and analyses mentioning Tau Protein in their description or question text
No additional research found