gene

PSP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

292Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	PSP
Full Name	Persephin
Chromosome	19q13.33
Protein Family	GDNF family
Function	Persephin mediates its effects through specific receptor interactions:
Pathways	Differentiation
GeneCards	PSP
Human Protein Atlas	PSP
SNR (Signal-to-Noise Ratio)	FA maps should have SNR > 20
Motion correction	Maximum displacement < 2mm between volumes
Eddy current correction	Proper preprocessing is essential
Artifact assessment	Check for slice dropout, Gibbs ringing
FA	Reduced in cerebral peduncles
MD	Elevated in PSP
RD	Elevated (reflects demyelination)
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's disease, Dementia
Interactions	VPS29, MAPT, GAL, MTOR, TAU, NLGN1
KG Connections	292 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PSP["PSP"] -->|"associated"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PSP["PSP"] -->|"associated"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PSP["PSP"] -->|"associated"| Alzheimer_s_disease["Alzheimer's disease"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PSP["PSP"] -->|"expressed in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    PSP["PSP"] -->|"associated"| frontotemporal_dementia["frontotemporal dementia"]
    style frontotemporal_dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PSP["PSP"] -->|"participates in"| oxidative_stress_response["oxidative stress response"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PSP["PSP"] -->|"biomarker for"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ALZHEIMER["ALZHEIMER"] -->|"associated"| PSP["PSP"]
    style ALZHEIMER fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DUSP10["DUSP10"] -->|"associated"| PSP["PSP"]
    style DUSP10 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MAP1S["MAP1S"] -->|"associated"| PSP["PSP"]
    style MAP1S fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TAU["TAU"] -->|"activates"| PSP["PSP"]
    style TAU fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| PSP["PSP"]
    style NEURODEGENERATIVE_DISEASES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style PSP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (202)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.85
Als	associated_with	disease	0.85
Alzheimer's disease	associated_with	disease	0.80
neurons	expressed_in	cell_type	0.80
ALZHEIMER'S DISEASE	associated_with	gene	0.80
SV2A	downregulates	protein	0.75
tauopathy	targets	disease	0.75
unfolded protein response	participates_in	pathway	0.75
STX6	regulates	gene	0.70
frontotemporal dementia	associated_with	disease	0.70
oxidative stress response	participates_in	pathway	0.70
Parkinson's disease	associated_with	disease	0.70
Parkinson's disease	regulates	disease	0.70
tauopathy	associated_with	disease	0.65
Ms	biomarker_for	disease	0.65
Dementia	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Tauopathy	activates	disease	0.65
Sarcopenia	therapeutic_target	disease	0.65
Aging	treats	disease	0.65
Als	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Als	treats	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Parkinson	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Aging	activates	disease	0.65
ALS	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tauopathy	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Neuropathy	inhibits	disease	0.65
Alzheimer	stabilizes	disease	0.65
Als	stabilizes	disease	0.65
Senescence	therapeutic_target	disease	0.65

Incoming (90)

Source	Relation	Type	Str
ALZHEIMER	associated_with	gene	0.70
MOBP	regulates	gene	0.70
DUSP10	associated_with	gene	0.60
MAP1S	associated_with	gene	0.60
TAU	activates	gene	0.60
PI3K	treats	gene	0.60
SNCA	therapeutic_target	gene	0.60
TAU	associated_with	gene	0.60
CDKN2A	associated_with	gene	0.60
TAU	expressed_in	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
P62	expressed_in	gene	0.60
AKT	activates	gene	0.60
PI3K	activates	gene	0.60
MAPT	activates	gene	0.60
NLGN1	inhibits	gene	0.60
TUBULIN	inhibits	gene	0.60
PI3K	associated_with	gene	0.60
PI3K	inhibits	gene	0.60
TAU	interacts_with	gene	0.60
PSMB7	associated_with	gene	0.60
SLC1A2	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
MAPT	regulates	gene	0.60
MAPT	expressed_in	gene	0.60
GBA	associated_with	gene	0.60
GBA	regulates	gene	0.60
C6	regulates	gene	0.60
GPR37	associated_with	gene	0.60
NFL	regulates	gene	0.60
C4A	regulates	gene	0.60
C4A	interacts_with	gene	0.60
C4A	causes	gene	0.60
APOE	regulates	gene	0.60
DUSP10	regulates	gene	0.60
EIF2AK3	regulates	gene	0.60
ABCA7	associated_with	gene	0.60
ATP13A2	associated_with	gene	0.60
BSN	associated_with	gene	0.60
CYLD	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
MYOD	regulates	gene	0.60
ROS	activates	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
P53	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	treats	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.507

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PSP

Understanding Entity Pages

Wiki Pages (21)

DTI White Matter Changes in CBS/PSP

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

CBS/PSP Rehabilitation Master Guide

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

Therapeutics

PI-2620 Tau PET in PSP

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

Pathway Diagram

Outgoing (202)

Incoming (90)

Targeting Hypotheses (0)

Mentioning Analyses (2)

4R-tau strain-specific spreading patterns in PSP vs CBD

4R-tau strain-specific spreading patterns in PSP vs CBD

Related Papers (0)