entity

tight junction

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about tight junction: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

6Hypotheses

3Analyses

2Outgoing

5Incoming

0Experiments

5Debates

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Outgoing (2)

Target	Relation	Type	Str
intestinal barrier integrity	regulates	process	0.90
Blood-Brain Barrier Permeability	regulates	phenotype	0.85

Incoming (5)

Source	Relation	Type	Str
CLDN5	involved_in	entity	0.95
OCLN	involved_in	entity	0.95
CLDN18	involved_in	protein	0.90
CLDN1	encodes	gene	0.90
TJP1	encodes	gene	0.90

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Bl	0.735	-	What blood-brain barrier permeability ch
Matrix Metalloproteinase-9/TIMP-1 Ratio in CSF Identifies Pr	0.675	-	What blood-brain barrier permeability ch
Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Bl	0.640	-	What blood-brain barrier permeability ch
Matrix Metalloproteinase-9-Mediated Claudin-5 Cleavage Drive	0.515	-	What blood-brain barrier permeability ch
C1q-Alectinib Complexation Disrupts Tight Junction Integrity	0.445	molecular-biology	Does Alectinib truly bind C1q directly w

Endocannabinoid-Mediated Tight Junction Stabilization	0.000	-	Blood-brain barrier tight junction disru