Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about white_matter_degeneration: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| CXCL10 | promotes | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive | 0.512 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| OPC differentiation blockade contributes to white matter deg | 0.495 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
| ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo | 0.493 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.692
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates. [PMID:41819088] | Liu L, Zheng Z, You W, Yang P, Wen Y et | Cell Metab | 2026 | 0 |
| [The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] | Wu K, Wang N, Zhao D, Wei W, Zhang W et | Zhejiang Da Xue Xue Bao Yi Xue | 2026 | 0 |
| Vitamin C slows primate aging by targeting iron-driven lipid peroxidation. [PMID:41950897] | Yu PL, Xu CR | Cell Metab | 2026 | 0 |
| The IL-33/ST2 Signaling Axis Alleviates Splenic Injury in Severe Acute Pancreati [PMID:41954769] | Cui L, Xu N, Chen J, Bin C, Feng Y et al | Pancreas | 2026 | 0 |
| Fibroblast-Specific GPX4 Deletion Exacerbates IBD via Lipid Peroxidation. [PMID:41955120] | Zhang Y, Ying Y, Huang W, Rosenfeld ZA, | Am J Physiol Gastrointest Live | 2026 | 0 |
| Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal St [PMID:41270149] | Li C, Teng T, Lin X, Sun X, Yi T et al. | Cancer Res | 2026 | 0 |
| A cellular epigenetic classification system for glioblastoma. [PMID:41499453] | Silverbush D, Jürgensen L, Freeburg NF, | Neuro Oncol | 2026 | 0 |
| Gastrointestinal Stromal Tumors: Molecular Mechanisms of Drug Resistance and Adv [PMID:41724491] | Jingnuo D, Huachuan Z, Da Z, Zhi D, Yan | J Gastroenterol Hepatol | 2026 | 0 |
| P16(+) Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated [PMID:41766526] | Yan L, Zheng J, Lu Z, Zhu A, Ye M et al. | Circulation | 2026 | 0 |
| Multi-omics reveals heterogeneity and functional populations of oligodendrocyte [PMID:41771834] | Ye D, Zhou H, Qu S, Wang Z, Zhang F et a | Cell Death Discov | 2026 | 0 |
| Comparison of gene fusion detection algorithms reveals frequently overlooked dri [PMID:41935182] | Tamura Z, Saito Y, Kogure Y, Oshikawa-Ku | NPJ Precis Oncol | 2026 | 0 |
| Single-cell transcriptome analysis indicated that immune-related programmed cell [PMID:41946148] | Sun J, Jing L, Zhu X, Yang H, Sun Y et a | Transl Oncol | 2026 | 0 |
| Lipid emulsion modulates myogenic and collagen-related gene expression in skelet [PMID:41955312] | Li X, Alaniz SM, Louey S, Deavila JM, Jo | Exp Physiol | 2026 | 0 |