Validation experiment designed to validate causal mechanisms targeting SNCA in Snca knockout mice. Primary outcome: time course of PFF clearance
This experiment examined the time course of clearance of α-synuclein preformed fibrils after injection into the olfactory bulb of Snca knockout mice. The purpose was to determine how quickly exogenously injected PFFs are cleared from brain tissue in the absence of endogenous α-synuclein expression. This provides baseline information about PFF persistence and clearance mechanisms.
PFFs injected into olfactory bulb with time-course analysis of remaining PFFs
PFFs would be cleared within a defined timeframe
complete clearance of injected PFFs
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