Clinical experiment designed to assess clinical efficacy targeting TFAM in human patients. Primary outcome: TFAM levels and mtDNA nucleoids in kidney tissue
Clinical study examining kidney tissue samples from acute kidney injury (AKI) patients to validate findings from animal and cell culture models. The study measured TFAM protein levels and mtDNA nucleoid structures in human kidney samples to determine whether the mitochondrial DNA maintenance defects observed in experimental models are also present in human AKI. This translational component aimed to establish clinical relevance of the mechanistic findings and support TFAM as a potential therapeutic target.
Analysis of kidney biopsy or tissue samples from AKI patients using immunohistochemistry and/or molecular techniques to assess TFAM expression and mtDNA nucleoid structure
AKI patients would show reduced TFAM levels and damaged mtDNA nucleoids similar to experimental models
Demonstrable loss of TFAM and mtDNA damage in human AKI kidney samples
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