🧫
Muscle-specific constitutive TUG cleavage mice study
active
experiment
Created: 2026-04-06T12:33:38
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-4d7e6704-cfa5-433b-996b-6f10fa011852
🧫 Experiment Protocol
ValidationMetabolic regulationTug (Aspscr1)Muscle-specific constitutive TUG cleavage miceproposed
Generation and analysis of mice with muscle-specific constitutive TUG cleavage to study the effects of continuous TUG C-terminal product availability. This model allowed researchers to examine the downstream effects of TUG cleavage on gene expression, thermogenesis, and metabolic regulation independent of insulin stimulation.
PRIMARY OUTCOME
Gene expression changes and thermogenesis
EXPECTED OUTCOMES
Enhanced thermogenesis and lipid oxidation due to continuous TUG C-terminal product activity
SUCCESS CRITERIA
Increased expression of thermogenic genes and enhanced energy expenditure
PROTOCOL
Generation of constitutive cleavage model, metabolic analysis, gene expression profiling, thermogenesis measurements
Source: PMID 33686286 ↗
🧫 Experiment Extras
PATHWAY
TUG-GLUT4 pathway, PPARγ/PGC-1α signaling, thermogenesis
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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