Validation experiment designed to validate causal mechanisms targeting SIRPα in conditional knockout mice. Primary outcome: synaptic density
This experiment used conditional knockout mice to specifically delete SIRPα in microglia and examined the effects on synaptic density. The researchers generated mice with microglial-specific deletion of SIRPα and measured synaptic density to understand the role of microglial SIRPα in synaptic pruning. The study aimed to determine whether loss of SIRPα in microglia affects baseline synaptic density under normal conditions.
Conditional knockout mouse generation with microglia-specific SIRPα deletion followed by synaptic density measurements
Decreased synaptic density following microglial SIRPα deletion
Significant reduction in synaptic density in SIRPα knockout mice compared to controls
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