🧫
Microglia-specific SIRPα deletion in conditional knockout mice
active
experiment
Created: 2026-04-10T23:10:58
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-b617e97f-5bfe-4d49-93cb-6af2674ce2f9
🧫 Experiment Protocol
ValidationSIRPαconditional knockout miceproposed
This experiment used conditional knockout mice to specifically delete SIRPα in microglia and examined the effects on synaptic density. The researchers generated mice with microglial-specific deletion of SIRPα and measured synaptic density to understand the role of microglial SIRPα in synaptic pruning. The study aimed to determine whether loss of SIRPα in microglia affects baseline synaptic density under normal conditions.
PRIMARY OUTCOME
synaptic density
EXPECTED OUTCOMES
Decreased synaptic density following microglial SIRPα deletion
SUCCESS CRITERIA
Significant reduction in synaptic density in SIRPα knockout mice compared to controls
PROTOCOL
Conditional knockout mouse generation with microglia-specific SIRPα deletion followed by synaptic density measurements
Source: PMID 33795678 ↗
🧫 Experiment Extras
PATHWAY
CD47-SIRPα signaling pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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