Validation experiment designed to validate causal mechanisms targeting GPR109A in C57BL/6J mice with periodontitis. Primary outcome: Restoration of GPR109A expression and reduction in inflammation
This experiment tested whether probiotic intervention could rescue periodontitis-induced intestinal dysfunction. The probiotic strain CBM588 was supplemented to two groups of mice with periodontitis (CP/LP groups) to evaluate its therapeutic potential in alleviating periodontitis-induced inflammation. The study specifically monitored GPR109A expression levels and inflammatory markers to determine if probiotic treatment could restore normal gut barrier function and reduce inflammation. This experiment served as a therapeutic intervention study to validate the mechanistic pathway identified in the initial periodontitis model.
Probiotic CBM588 supplementation in periodontitis mice, followed by GPR109A expression analysis and inflammatory marker assessment
Probiotic supplementation would restore GPR109A expression and reduce inflammation
Significant restoration of GPR109A levels and improvement in barrier function markers
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