🧫
Probiotic CBM588 supplementation rescue experiment
active
experiment
Created: 2026-04-10T22:49:24
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-cafc6e59-f753-4298-bee2-7b0dc9047ff2
🧫 Experiment Protocol
ValidationPeriodontitis-associated intestinal inflammationGPR109AC57BL/6J mice with periodontitisproposed
This experiment tested whether probiotic intervention could rescue periodontitis-induced intestinal dysfunction. The probiotic strain CBM588 was supplemented to two groups of mice with periodontitis (CP/LP groups) to evaluate its therapeutic potential in alleviating periodontitis-induced inflammation. The study specifically monitored GPR109A expression levels and inflammatory markers to determine if probiotic treatment could restore normal gut barrier function and reduce inflammation. This experiment served as a therapeutic intervention study to validate the mechanistic pathway identified in the initial periodontitis model.
PRIMARY OUTCOME
Restoration of GPR109A expression and reduction in inflammation
EXPECTED OUTCOMES
Probiotic supplementation would restore GPR109A expression and reduce inflammation
SUCCESS CRITERIA
Significant restoration of GPR109A levels and improvement in barrier function markers
PROTOCOL
Probiotic CBM588 supplementation in periodontitis mice, followed by GPR109A expression analysis and inflammatory marker assessment
Source: PMID 41816355 ↗
🧫 Experiment Extras
PATHWAY
Probiotic-mediated restoration of GPR109A signaling
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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