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GPR109A

Hydroxycarboxylic Acid Receptor 2 (HCAR2)

Score: 0.718 Price: $0.60 High Druggability Status: active
HYPOTHESES
1
PAPERS
21
KG EDGES
0
DEBATES
0

3D Protein Structure

🧬 GPR109A — PDB 7SK3 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability
High
Score: 0.50
Clinical Stage
Phase III
Target Class
Receptor
Safety
0.50
Druggability Analysis
Drug Development0.00
Structural Tractability0.30
Target Class0.70
Safety Profile0.50
Key Metrics
PDB Structures:
0
Known Drugs:
0
Approved:
0
In Clinical Trials:
0
Therapeutic Areas:
neurodegeneration
Mechanism: Prioritized from 1 SciDEX hypotheses, including: Targeted Butyrate Supplementation for Microglial Phenotype Modulation
Known Drugs:
No known drugs targeting this protein
Structural Data:

🧬 3D Protein Structure

🧬 GPR109A — PDB 7SK3 Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

Linked Hypotheses (1)

Targeted Butyrate Supplementation for Microglial Phenotype Modulation0.559

Linked Experiments (4)

Periodontitis-induced colonic inflammation in mice0.900
Fecal microbiota transplantation from periodontitis donors0.900
GPR109A functional modulation with pharmacological agents0.880
Probiotic CBM588 supplementation rescue experiment0.850

Scoring Dimensions

Portfolio 0.00 (25%) Druggability 0.50 (20%) Evidence 1.00 (20%) Safety 0.50 (15%) Competitive 0.70 (10%) Connectivity 0.00 (10%) 0.718 composite

Knowledge Graph (20)

activates (10)

GPR109A → MERTK
GPR109A → HDAC1
GPR109A → PPAR
GPR109A → TLR4
GPR109A → CD14
...and 5 more

associated with (1)

GPR109A → neurodegeneration

co discussed (4)

GPR109A → AADC
GPR109A → CHRNA7
GPR109A → AGER
GPR109A → CSGA

expressed in (1)

GPR109A → TNF

inhibits (1)

GPR109A → GSDMD

protects against (1)

GPR109A → Rb

regulates (1)

GPR109A → Osteoclast

therapeutic target (1)

GPR109A → MET

Debate History (0)

No debates yet

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