GPR109A

Hydroxycarboxylic Acid Receptor 2 (HCAR2)

Score: 0.400 Price: $0.40 Low Druggability Status: active

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 GPR109A — PDB 7SK3 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Low

Score: 0.28

Clinical Stage

Preclinical

Target Class

Receptor

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.70

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Drug Pipeline (10 compounds)

10 Preclinical

Mechanism: Prioritized from 1 SciDEX hypotheses, including: Targeted Butyrate Supplementation for Microglial Phenotype Modulation

Drug Pipeline (10 compounds)

10 Preclinical

Known Drugs:

CHEMBL235256 (preclinical)

CHEMBL237248 (preclinical)

CHEMBL237543 (preclinical)

CHEMBL237247 (preclinical)

CHEMBL237037 (preclinical)

CHEMBL237036 (preclinical)

CHEMBL236164 (preclinical)

CHEMBL391813 (preclinical)

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: Q8TDS4

🧬 3D Protein Structure

🧬 GPR109A — PDB 7SK3 Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

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AlphaFold predicted structure available for Q8TDS4

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Clinical Trials (1)

Relevant trials from ClinicalTrials.gov

Active

Completed

Total Enrollment

By Phase

NA: 1

GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures Completed

NA NCT03462680 n=47

Parkinson's Disease

Interventions: niacin, placebo

Sponsor: VA Office of Research and Development | Started: 2016-09-28

Linked Hypotheses (1)

Targeted Butyrate Supplementation for Microglial Phenotype Modulation0.805

Linked Experiments (4)

Periodontitis-induced colonic inflammation in mice0.900

Fecal microbiota transplantation from periodontitis donors0.900

GPR109A functional modulation with pharmacological agents0.880

Probiotic CBM588 supplementation rescue experiment0.850

Scoring Dimensions

Knowledge Graph (20)

activates (10)

Esketamine→GPR109ABeta-hydroxybutyrate→GPR109ANiacin→GPR109AAcifran→GPR109AGPR109A→PKA/PPARγ/MerTK pathway

▸ Show 5 more

GPR109A→MERTKTLR4→GPR109ACD14→GPR109ATLR2→GPR109AGPR109A→HDAC1

▸ Show 2 more

GPR109A→AGERGPR109A→CSGA

contributes to (1)

GPR109A→Hepatocellular carcinoma

Debate History (1)

Should GPR109A (Hydroxycarboxylic Acid Receptor 2 (HCAR2)) be prioritized as a t2026-04-22