🧫
α7nAChR agonist treatment rescues HFD-induced memory deficits
active
experiment
Created: 2026-04-10T22:50:30
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-d8bfd8d9-639f-433e-9e74-25587b83e81f
🧫 Experiment Protocol
Validationdiet-induced cognitive dysfunctionCHRNA7HFD-fed adult Swiss male miceproposed
HFD-fed mice received intracerebroventricular treatment with PNU-282987, a selective α7 nicotinic acetylcholine receptor agonist, for 3 days to determine if cholinergic activation could mitigate HFD-induced cognitive impairments and neuroinflammation. This pharmacological intervention experiment tested whether targeted activation of α7nAChR could reverse the negative effects of high-fat diet on memory and inflammation in the hippocampal CA3 region. The treatment was administered directly to the brain to ensure specific targeting of central cholinergic receptors.
PRIMARY OUTCOME
rescue of memory performance and reduction of neuroinflammation
EXPECTED OUTCOMES
PNU-282987 treatment would improve memory performance and reduce neuroinflammation in HFD-fed mice
SUCCESS CRITERIA
Restoration of memory function and inflammatory markers to control levels
PROTOCOL
Intracerebroventricular administration of PNU-282987 for 3 days in HFD-fed mice, followed by behavioral and molecular analysis
LINKED HYPOTHESES
Source: PMID 41565126 ↗
🧫 Experiment Extras
PATHWAY
cholinergic anti-inflammatory pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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