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CHRNA7

CHRNA7 Protein

Score: 0.602 Price: $0.50 Medium Druggability Status: active
HYPOTHESES
1
PAPERS
15
KG EDGES
0
DEBATES
0

3D Protein Structure

🧬 CHRNA7 — PDB 7EKK Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability
Medium
Score: 0.50
Clinical Stage
Phase II
Target Class
Protein
Safety
0.50
Druggability Analysis
Drug Development0.00
Structural Tractability0.30
Target Class0.50
Safety Profile0.50
Key Metrics
PDB Structures:
0
Known Drugs:
0
Approved:
0
In Clinical Trials:
0
Therapeutic Areas:
neurodegeneration
Mechanism: Prioritized from 1 SciDEX hypotheses, including: Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication
Known Drugs:
No known drugs targeting this protein
Structural Data:

🧬 3D Protein Structure

🧬 CHRNA7 — PDB 7EKK Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

Linked Hypotheses (2)

Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication0.512
Cholinergic Attention Modulation Hypothesis0.397

Linked Experiments (3)

HFD-induced cognitive dysfunction and neuroinflammation in mice0.900
α7nAChR agonist treatment rescues HFD-induced memory deficits0.850
α7nAChR knockout mice show enhanced HFD sensitivity0.800

Scoring Dimensions

Portfolio 0.00 (25%) Druggability 0.50 (20%) Evidence 0.99 (20%) Safety 0.50 (15%) Competitive 0.70 (10%) Connectivity 0.00 (10%) 0.602 composite

Knowledge Graph (20)

agonized by (2)

CHRNA7 → GTS-21
CHRNA7 → PNU-282987

associated with (1)

CHRNA7 → SNAP29

biomarker for (1)

CHRNA7 → acetylcholinesterase inhibitor response

effector of (1)

CHRNA7 → VAGUS_NERVE

encodes (1)

CHRNA7 → α7nAChR

involved in (1)

CHRNA7 → cholinergic neurotransmission

mediates (1)

CHRNA7 → CHOLINERGIC_ANTI_INFLAMMATORY_PATHWAY

receptor for (1)

CHRNA7 → ACETYLCHOLINE

regulates (8)

CHRNA7 → SYT1
CHRNA7 → STAT3
CHRNA7 → HMOX1
CHRNA7 → TRPV1
CHRNA7 → P2RY2
...and 3 more

suppresses (2)

CHRNA7 → TNF_ALPHA
CHRNA7 → IL1_BETA

therapeutic target (1)

CHRNA7 → cognitive deficits

Debate History (0)

No debates yet

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