🧫
Single-nucleus RNA sequencing of temporal neocortex showed nominally increased mosaic chromosomal alterations associated with clonal hematopoiesis; microglia carrying mCA exhibited upregulated pro-inflammatory genes resembling disease-associated microglia (DAM) signature.
active
experiment
Created:
By: experiment_extractor
Quality:
50%
✓ SciDEX
ID: experiment-exp-09047c9e881d
🧫 Experiment Protocol
Gene Expressionproposed
SUMMARY
Single-nucleus RNA sequencing of temporal neocortex showed nominally increased mosaic chromosomal alterations associated with clonal hematopoiesis; microglia carrying mCA exhibited upregulated pro-inflammatory genes resembling disease-associated microglia (DAM) signature.
METHODOLOGY NOTES
snRNAseq analysis of 62 additional AD cases and controls; mosaic chromosomal alteration (mCA) detection
N = {'case': None, 'total': 62, 'units': 'subjects', 'control': None}tissue: temporal neocortexspecies: homo_sapiens
Related Entities
▸Metadatasource: {'pmid': '38260600', 'type': 'paper', 'e
| source | {'pmid': '38260600', 'type': 'paper', 'extracted_by': 'llm_extraction_v1'} |
| tissue | temporal neocortex |
| species | homo_sapiens |
| summary | Single-nucleus RNA sequencing of temporal neocortex showed nominally increased mosaic chromosomal alterations associated with clonal hematopoiesis; microglia carrying mCA exhibited upregulated pro-inf |
| sample_size | {'case': None, 'total': 62, 'units': 'subjects', 'control': None} |
| model_system | in_vivo |
| _schema_version | 1 |
| experiment_type | gene_expression |
| methodology_notes | snRNAseq analysis of 62 additional AD cases and controls; mosaic chromosomal alteration (mCA) detection |
| replication_status | replicated |
| extraction_metadata | {'needs_review': False, 'extraction_date': '2026-04-28T06:18:28.449279+00:00', 'extraction_notes': '', 'extraction_confidence': 0.5} |
| statistical_evidence | {'p_value': None, 'test_type': None, 'effect_size': {'value': None, 'measure': 'nominally increased mCAs', 'direction': 'increased'}} |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.