Antidepressant effects of aminophylline in chronic restraint stress mice

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active

experiment Created: 2026-04-10T22:36:02 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-a35264b6-1000-4448-a809-0

🧫 Experiment Protocol Animal Modelproposed

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T22:36:02.771126'}
p_value	None
protocol	15-day chronic restraint stress protocol with 4-hour daily stress exposure, daily intraperitoneal injections of aminophylline or fluoxetine, behavioral testing on days 0, 5, 10, and 15 using TST, FST,
effect_size	None
sample_size	None
source_pmid	41945313
extracted_at	2026-04-10T15:36:02.768446
_schema_version	1
experiment_type	animal_model
success_criteria	significant reduction in immobility time in TST and FST, increased grooming time in SST compared to stressed controls
expected_outcomes	reduction in immobility time and increase in grooming activity indicating antidepressant effects
statistical_methods	None

📊 Evidence Profile

Evidence Balance

+0%

Certainty

30%

Debates

0

Incoming

6

Outgoing

5

0 supporting 0 contradicting 0 neutral

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💬 Discussion