🧫
Bulk RNA sequencing of 866 brain samples revealed significantly higher (~two-fold) overall burden of somatic single-nucleotide variants in AD brains compared to age-matched controls.
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experiment
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✓ SciDEX
ID: experiment-exp-dff164a6df75
🧫 Experiment Protocol
Genetic Associationproposed
SUMMARY
Bulk RNA sequencing of 866 brain samples revealed significantly higher (~two-fold) overall burden of somatic single-nucleotide variants in AD brains compared to age-matched controls.
METHODOLOGY NOTES
Three orthogonal methods used across three independent AD cohorts; bulk RNA sequencing approach for variant detection
N = {'case': None, 'total': 866, 'units': 'samples', 'control': None}tissue: multiple brain regions (prefrontal cortex, temporal neocortex)species: homo_sapiens
Related Entities
▸Metadatasource: {'pmid': '38260600', 'type': 'paper', 'e
| source | {'pmid': '38260600', 'type': 'paper', 'extracted_by': 'llm_extraction_v1'} |
| tissue | multiple brain regions (prefrontal cortex, temporal neocortex) |
| species | homo_sapiens |
| summary | Bulk RNA sequencing of 866 brain samples revealed significantly higher (~two-fold) overall burden of somatic single-nucleotide variants in AD brains compared to age-matched controls. |
| sample_size | {'case': None, 'total': 866, 'units': 'samples', 'control': None} |
| model_system | in_vivo |
| _schema_version | 1 |
| experiment_type | genetic_association |
| methodology_notes | Three orthogonal methods used across three independent AD cohorts; bulk RNA sequencing approach for variant detection |
| replication_status | replicated |
| extraction_metadata | {'needs_review': False, 'extraction_date': '2026-04-28T06:18:28.439960+00:00', 'extraction_notes': '', 'extraction_confidence': 0.5} |
| statistical_evidence | {'p_value': None, 'test_type': None, 'effect_size': {'value': 2, 'measure': 'fold change', 'direction': 'increased'}} |
📊 Evidence Profile
Evidence Balance
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