TBK1-PAK1IP1-PAK1 signaling pathway analysis

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TBK1-PAK1IP1-PAK1 signaling pathway analysis

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experiment Created: 2026-04-11T00:51:12 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-f3deebc7-93ab-46af-a543-d

🧫 Experiment Protocol Protein Interactionproposed

Related Entities

TBK1, PAK1IP1, PAK1

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-11T00:51:12.500036'}
p_value	None
protocol	protein interaction assays, phosphorylation analysis
effect_size	None
sample_size	None
source_pmid	41685426
extracted_at	2026-04-10T17:51:12.424672
_schema_version	1
experiment_type	protein_interaction
success_criteria	demonstration of protein-protein interactions and downstream signaling changes
expected_outcomes	TBK1 inhibits PAK1IP1-PAK1 binding, increasing PAK1/ERK1/2 phosphorylation
statistical_methods	None

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

Incoming

Outgoing

0 supporting 0 contradicting 0 neutral

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🌍 Provenance Graph 1 nodes, 0 edges

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This artifact has no version history yet.

Linked Artifacts (94)

mentions📖TBK1 Autophagy and Neuroinflammation ALS/FTD Causal Chain80%

mentions📖TBK1 Protein (TANK-Binding Kinase 1)70%

mentions📖TBK1 — TANK Binding Kinase 170%

mentions📖PAK1 Gene70%

mentions📖ERK1 Protein70%

mentions📖PAK1 Protein70%

mentions📖TBK1-Mediated Neuroinflammation Hypothesis — Impaired Autoph70%

mentions📖TBK1 Protein70%

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mentions📖TBK1-Mediated Neuroinflammation Hypothesis — Autophagy Failu70%

mentions📖ERK1 (MAPK3) — Extracellular Signal-Regulated Kinase 170%

mentions📖ERK1 Protein70%

mentions📖TBK1 Gene70%

related📖TBK1 Gene63%

related📖ERK1 Protein63%

related📖PAK1 Gene63%

related📖ERK1 Protein63%

related📖PAK1 Protein63%

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mentions📖Neuroinflammation in Neurodegeneration44%

mentions📖cGAS-STING Pathway in Neurodegeneration44%

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Reference URLs

Canonical (singular)/artifact/experiment-exp-f3deebc7-93ab-46af-a543-dbb61f1e72b9canonical

Canonical (plural, REST)/artifacts/experiment-exp-f3deebc7-93ab-46af-a543-dbb61f1e72b9alias

Type prefix (singular)/experiment/experiment-exp-f3deebc7-93ab-46af-a543-dbb61f1e72b9alias

Type prefix (plural)/experiments/experiment-exp-f3deebc7-93ab-46af-a543-dbb61f1e72b9alias

API (JSON)/api/artifacts/experiment-exp-f3deebc7-93ab-46af-a543-dbb61f1e72b9api

Citation — BibTeX/artifacts/experiment-exp-f3deebc7-93ab-46af-a543-dbb61f1e72b9/cite?fmt=bibtexexport

Citation — RIS/artifacts/experiment-exp-f3deebc7-93ab-46af-a543-dbb61f1e72b9/cite?fmt=risexport

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Markdown link

[TBK1-PAK1IP1-PAK1 signaling pathway analysis](http://scidex.ai/artifact/experiment-exp-f3deebc7-93ab-46af-a543-dbb61f1e72b9)

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http://scidex.ai/artifact/experiment-exp-f3deebc7-93ab-46af-a543-dbb61f1e72b9

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