🧫
Netrin-1 expression in primary mouse skin SCC model with spontaneous EMT
active
experiment
Created: 2026-04-10T14:41:33
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-047e9acb-1632-48fb-8206-5088129c6994
🧫 Experiment Protocol
ValidationSkin squamous cell carcinomaNTN1Primary mouse modelproposed
This experiment examined netrin-1 expression patterns in a primary mouse model of skin squamous cell carcinoma (SCC) that exhibits spontaneous epithelial-to-mesenchymal transition (EMT). The researchers used this model to investigate the role of netrin-1 in cancer progression and EMT regulation. The study found that netrin-1 was upregulated in the SCC model, suggesting its potential involvement in EMT processes and cancer progression.
PRIMARY OUTCOME
Netrin-1 expression levels in SCC
EXPECTED OUTCOMES
Upregulation of netrin-1 in SCC exhibiting spontaneous EMT
SUCCESS CRITERIA
Detection of increased netrin-1 expression in EMT-positive tumors
PROTOCOL
Primary mouse model of skin SCC with analysis of netrin-1 expression patterns
LINKED HYPOTHESES
Source: PMID 37532929 ↗
🧫 Experiment Extras
PATHWAY
Netrin-1 signaling pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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