🧫
Multi-omics analysis of NP137 mechanism in patient biopsies
active
experiment
Created: 2026-04-10T14:41:11
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-195dc00d-9834-40cb-b078-0ba044ff1768
🧫 Experiment Protocol
Exploratoryendometrial carcinomaNTN1human patient biopsiesproposed
Comprehensive molecular analysis using bulk RNA sequencing, spatial transcriptomics, and single-cell RNA sequencing on paired pre-treatment and on-treatment biopsies from endometrial carcinoma patients in the NP137 trial. This multi-omics approach aimed to elucidate the mechanism of action of netrin-1 blockade at the molecular level. The analysis revealed a net reduction in tumor EMT signatures, changes in immune infiltrate composition, and increased interactions between cancer cells and the tumor microenvironment, providing mechanistic insights into how NP137 exerts its therapeutic effects.
PRIMARY OUTCOME
EMT signature reduction and immune infiltrate changes
EXPECTED OUTCOMES
Reduced EMT signatures and altered tumor microenvironment
SUCCESS CRITERIA
Significant changes in EMT markers and immune cell populations
PROTOCOL
Bulk RNA-seq, spatial transcriptomics, and single-cell RNA-seq on paired biopsies
LINKED HYPOTHESES
Source: PMID 37532934 ↗
🧫 Experiment Extras
PATHWAY
EMT pathway, immune signaling pathways
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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