🧫
Enteric Alpha-Synuclein Propagation and ENS Dysfunction in PD Mouse Model
active
experiment
Created: 2026-04-26T06:56:03
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-2c20043e4b80
🧫 Experiment Protocol
In-VivoParkinson diseaseMouse (C57BL/6 or Thy1-αSyn transgenic), gut injection modelproposed
Determine whether alpha-synuclein fibrils injected into the gut lumen propagate via the vagus nerve to the brainstem and whether ENS dysfunction constitutes a self-reinforcing feedback loop in a preformed PD mouse model.
PRIMARY OUTCOME
p-Syn (Ser129) pathology burden in vagus nerve and brainstem DMV
EXPECTED OUTCOMES
Alpha-synuclein pathology detected in vagus nerve and dorsal motor nucleus by 6 months post-injection, with progressive ENS dysfunction evidenced by delayed gut transit.
SUCCESS CRITERIA
p-Syn (Ser129) IHC in vagus and DMV; threshold: pathology score > 2 in treatment vs. control groups.
PROTOCOL
in-vivo
Source: auto-generated
🧫 Experiment Extras
ESTIMATED COST
$48,000
TIMELINE
12 months
MARKET PRICE
$0.50
STATUS
proposed
Scoring Dimensions
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.