🧫
Theta-Gamma Coupling Restoration Through PV Interneuron Optogenetic Modulation
active
experiment
Created: 2026-04-26T06:56:03
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-3cc32260e348
🧫 Experiment Protocol
In-VivoAlzheimer diseaseMouse (5xFAD or kcng1-tau model) with chronic implanted electrodes/optrodesproposed
Determine whether closed-loop optogenetic PV interneuron stimulation can restore theta-gamma coupling and improve spatial memory in a mouse model of AD or epilepsy with documented coupling deficits.
PRIMARY OUTCOME
LFP theta-gamma coupling and spatial memory performance (MWM)
EXPECTED OUTCOMES
Closed-loop stimulation restores theta-gamma coupling (phase-amplitude coupling index restored to >80% of baseline) and improves spatial memory performance (Morris water maze) vs. open-loop or no-stimulation controls.
SUCCESS CRITERIA
LFP theta-gamma PAC (phase-amplitude coupling) and Morris water maze latency; threshold: p < 0.05 for both.
PROTOCOL
in-vivo
Source: auto-generated
🧫 Experiment Extras
ESTIMATED COST
$50,000
TIMELINE
12 months
MARKET PRICE
$0.50
STATUS
proposed
Scoring Dimensions
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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