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Single-cell/multiomics analysis of 84 human post-mortem brains revealed two AD disease phases: early phase characterized by inflammatory microglia, reactive astrocytes, loss of SST+ inhibitory neurons and OPC remyelination; later phase showing exponential pathology increase and loss of excitatory an
active
experiment
Created: 2026-04-27T23:14:30
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-5641ae1b076a
🧫 Experiment Protocol
ComputationalAlzheimer's diseasehumanextracted
Multiomics and spatial genomics using BRAIN Initiative reference atlases; donors placed on disease pseudoprogression score using quantitative neuropathology; replication in other major AD studies
PRIMARY OUTCOME
Single-cell/multiomics analysis of 84 human post-mortem brains revealed two AD disease phases: early phase characterized by inflammatory microglia, reactive astrocytes, loss of SST+ inhibitory neurons and OPC remyelination; later phase showing exponential pathology increase and loss of excitatory and Pvalb+/Vip+ inhibitory neurons.
LINKED HYPOTHESES
Source: pmid_39402379
🧫 Experiment Extras
MARKET PRICE
$0.50
STATUS
extracted
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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