🧫
IRI-AKI mouse model with mtROS inhibition
active
experiment
Created: 2026-04-10T14:43:05
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-7fb152da-1495-4cd3-bdf8-ec21512d6529
🧫 Experiment Protocol
Validationischemic acute kidney injuryTFAMIRI-AKI miceproposed
In vivo study using a mouse model of ischemia-reperfusion injury-induced acute kidney injury (IRI-AKI) to investigate the effects of mitochondrial ROS (mtROS) inhibition on renal function, mitochondrial function, and inflammation. Mice underwent renal ischemia-reperfusion with or without mtROS inhibitor treatment, followed by assessment of kidney function, mitochondrial parameters, and inflammatory markers. This experiment aimed to establish the causal role of mtROS in IRI-AKI pathogenesis.
PRIMARY OUTCOME
renal function, mitochondrial damage, and inflammation
EXPECTED OUTCOMES
mtROS inhibition would attenuate renal dysfunction, mitochondrial damage, and inflammation
SUCCESS CRITERIA
Significant improvement in renal function parameters and reduction in mitochondrial damage and inflammation with mtROS inhibition
PROTOCOL
Renal ischemia-reperfusion surgery with or without mtROS inhibitor treatment, followed by analysis of renal function parameters, mitochondrial function markers, and inflammatory cytokines
LINKED HYPOTHESES
Source: PMID 33408785 ↗
🧫 Experiment Extras
PATHWAY
mitochondrial DNA maintenance
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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