🧫
Butyrate treatment on microglial cytokine expression in aged mice
active
experiment
Created: 2026-04-10T23:12:36
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-826a901a-58b2-4fb4-aa16-f0df89344018
🧫 Experiment Protocol
Validationage-related neuroinflammationaged mice microgliaproposed
This experiment investigated the direct effects of butyrate on pro-inflammatory cytokine expression in microglia from aged mice. The study demonstrated that butyrate treatment can attenuate pro-inflammatory cytokine expression in microglia, suggesting its potential as an anti-inflammatory therapeutic agent for age-related neuroinflammation. This appears to be a preliminary experiment that provided the rationale for the subsequent dietary fiber intervention study.
PRIMARY OUTCOME
pro-inflammatory cytokine expression levels
EXPECTED OUTCOMES
Reduced pro-inflammatory cytokine expression in microglia
SUCCESS CRITERIA
Significant attenuation of pro-inflammatory cytokine expression
PROTOCOL
Direct butyrate treatment of microglia with measurement of cytokine expression
Source: PMID 30154787 ↗
🧫 Experiment Extras
PATHWAY
neuroinflammation, microglial activation
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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