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MitoPark mice were used to model PD progression, showing that Anxa1+ dopaminergic neurons are selectively lost earlier than other neuronal subtypes, with degeneration aligning with motor symptom development.

active
experiment Created: 2026-04-27T23:27:43 By: etl-v1-backfill Quality: 50% ✓ SciDEX ID: exp-db3fcfec39aa
🧫 Experiment Protocol Animal ModelParkinson's diseasemouseextracted
MitoPark mice model mitochondrial dysfunction in DANs; time course of Anxa1+ neuronal loss compared to motor symptom onset
PRIMARY OUTCOME
MitoPark mice were used to model PD progression, showing that Anxa1+ dopaminergic neurons are selectively lost earlier than other neuronal subtypes, with degeneration aligning with motor symptom development.
Source: pmid_39763754
🧫 Experiment Extras
MARKET PRICE
$0.50
STATUS
extracted
Metadataorigin_type: v1_polymorphic_backfill
origin_typev1_polymorphic_backfill
source_tableexperiments
_schema_version1
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
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0 supporting 0 contradicting 0 neutral
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