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Multimodal cell atlas analysis of 84 human AD donor brains identified two disease phases: an early phase with inflammatory microglia, reactive astrocytes, somatostatin+ inhibitory neuron loss, and remyelination by OPCs; and a later phase with exponential pathology increase, excitatory neuron loss, a
active
experiment
Created:
By: experiment_extractor
Quality:
50%
✓ SciDEX
ID: experiment-exp-bf66d02f24c1
🧫 Experiment Protocol
Computationalproposed
SUMMARY
Multimodal cell atlas analysis of 84 human AD donor brains identified two disease phases: an early phase with inflammatory microglia, reactive astrocytes, somatostatin+ inhibitory neuron loss, and remyelination by OPCs; and a later phase with exponential pathology increase, excitatory neuron loss, and Pvalb+/Vip+ inhibitory neuron subtype loss.
METHODOLOGY NOTES
Multiomics, spatial genomics, and quantitative neuropathology applied to BRAIN Initiative reference atlases. Donors (33 male, 51 female; mean age 88) were stratified using a disease pseudoprogression score based on neuropathology.
N = {'case': None, 'total': 84, 'units': 'subjects', 'control': None}tissue: middle temporal gyrusspecies: homo_sapiens
▸Metadatasource: {'pmid': '39402379', 'type': 'paper', 'e
| source | {'pmid': '39402379', 'type': 'paper', 'extracted_by': 'llm_extraction_v1'} |
| tissue | middle temporal gyrus |
| species | homo_sapiens |
| summary | Multimodal cell atlas analysis of 84 human AD donor brains identified two disease phases: an early phase with inflammatory microglia, reactive astrocytes, somatostatin+ inhibitory neuron loss, and rem |
| sample_size | {'case': None, 'total': 84, 'units': 'subjects', 'control': None} |
| model_system | human |
| _schema_version | 1 |
| experiment_type | computational |
| methodology_notes | Multiomics, spatial genomics, and quantitative neuropathology applied to BRAIN Initiative reference atlases. Donors (33 male, 51 female; mean age 88) were stratified using a disease pseudoprogression |
| replication_status | replicated |
| extraction_metadata | {'needs_review': False, 'extraction_date': '2026-04-28T06:21:38.643090+00:00', 'extraction_notes': '', 'extraction_confidence': 0.5} |
| statistical_evidence | None |
📊 Evidence Profile
Evidence Balance
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Certainty
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Debates
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0 supporting
0 contradicting
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