The abstract reveals that helicases like DDX1, DDX17, and DHX9 can both form and resolve R-loops, but the molecular switches governing this dual functionality are unknown. Understanding these mechanisms is critical since R-loop dysregulation contributes to neurodegeneration in diseases like ALS and ataxias. Gap type: unexplained_observation Source paper: Helicases in R-loop Formation and Resolution. (2023, The Journal of biological chemistry, PMID:37778731)
Landscape Summary: What determines whether helicases promote R-loop formation versus resolution in the same cellular context? is a 0.8 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What determines whether helicases promote R-loop formation versus resolution in the same cellular context? — INVOKE-2 (completed)
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