concept

M6A MODIFICATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about M6A MODIFICATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections

1Hypotheses

2Analyses

32Outgoing

20Incoming

0Experiments

3Debates

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💡 Concept Info

Name	M6A MODIFICATION

Pathway Diagram

graph TD
    M6A_MODIFICATION["M6A MODIFICATION"]
    M6A_MODIFICATION -->|"regulates"| Rna_Metabolism["Rna Metabolism"]
    M6A_MODIFICATION -->|"modulates"| Neuronal_Function["Neuronal Function"]
    M6A_MODIFICATION -->|"modulates"| PIEZO2["PIEZO2"]
    M6A_MODIFICATION -->|"modulates"| RNA["RNA"]
    M6A_MODIFICATION -->|"contributes to"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    M6A_MODIFICATION -->|"contributes to"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    M6A_MODIFICATION -->|"contributes to"| ALS["ALS"]
    M6A_MODIFICATION -->|"involved_in"| Biological_Functions["Biological Functions"]
    METTL3["METTL3"] -->|"catalyzes"| M6A_MODIFICATION
    METTL14["METTL14"] -->|"catalyzes"| M6A_MODIFICATION
    METTL16["METTL16"] -->|"catalyzes"| M6A_MODIFICATION
    YTHDF1["YTHDF1"] -->|"binds"| M6A_MODIFICATION
    YTHDF2["YTHDF2"] -->|"binds"| M6A_MODIFICATION
    YTHDF3["YTHDF3"] -->|"binds"| M6A_MODIFICATION
    FTO["FTO"] -->|"modulates"| M6A_MODIFICATION
    ALKBH5["ALKBH5"] -->|"modulates"| M6A_MODIFICATION

Outgoing (32)

Target	Relation	Type	Str
Rna Metabolism	regulates	process	0.95
Neuronal Function	modulates	process	0.95
PIEZO2	modulates	gene	0.93
ALZHEIMER'S DISEASE	contributes_to	disease	0.90
Cancer progression	drives	process	0.90
Parkinson's disease	associated_with	disease	0.90
Cancer	involved_in	disease	0.90
PARKINSON'S DISEASE	contributes_to	disease	0.90
R-Loops	regulates	mechanism	0.90
ALS	contributes_to	disease	0.90
Biological Functions	involved_in	process	0.88
R-loop	suppresses	process	0.88
HPV early transcript expression	regulates	process	0.87
Cancer Initiation	involved_in	process	0.85
Cancer Progression	involved_in	process	0.85
Disease	associated_with	disease	0.85
Dopaminergic Neuron Survival	modulates	process	0.85
Hpv Replication	regulates	process	0.85
Phospho-Α-Synuclein	regulates	biomarker	0.85
APOPTOSIS	contributes_to	process	0.85
MITOCHONDRIA	modulates	cell_type	0.85
AUTOPHAGY	regulates	process	0.85
hematopoietic system	regulates	cell_type	0.80
Physiological Functions	involved_in	process	0.80
central nervous system	regulates	brain_region	0.80
Stress Granule Formation	modulates	process	0.80
ALS	modulates	disease	0.80
reproductive system	regulates	cell_type	0.80
INFLAMMATION	modulates	process	0.80
Pathological Conditions	involved_in	process	0.80
alpha-synuclein transcript fate	regulates	mechanism	0.70
alpha-synuclein aggregation kinetics	modulates	mechanism	0.70

Incoming (20)

Source	Relation	Type	Str
YTHDF1	associated_with	protein	0.95
YTHDF3	binds	protein	0.95
YTHDF2	binds	protein	0.95
METTL3	mediates	gene	0.95
METTL14	mediates	gene	0.95
METTL16	catalyzes	enzyme	0.95
SETX	activates	gene	0.92
FTO	inhibits	gene	0.90
ALKBH5	inhibits	gene	0.90
FTO	modulates	gene	0.90
RBM15	involved_in	protein	0.90
METTL3	regulates	gene	0.90
IGF2BP1	binds	protein	0.90
VIRMA	mediates	gene	0.85
cell differentiation	upregulates	process	0.85
WTAP	mediates	gene	0.85
WTAP	regulates	protein	0.85
RBM15	regulates	protein	0.85
S-adenosylmethionine	associated_with	compound	0.85
Viral Early Transcripts	associated_with	biomarker	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
METTL3-Mediated m6A Modification of lncRNA-0021 Regulates mi	0.769	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp

Mentioning Analyses (2)

Scientific analyses that reference this entity

m6A RNA Modification and Alpha-Synuclein Aggregation in Substantia Nigra

neurodegeneration | 2026-04-27 | 4 hypotheses Top: 0.662

What determines the specificity of RNA-protein interactions that drive distinct

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.712

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

How does N6-methyladenosine (m6A) RNA modification alter alpha-synuclein mRNA st

closed · Rounds: 4 · Score: 0.67 · 2026-04-28

Debate: Liquid-to-Solid Transition Pathology Reveals Granule Weak Points

closed · Rounds: 4 · Score: 0.58 · 2026-04-27

While the study identifies G3BP1 as a central node triggering phase separation,

closed · Rounds: 4 · Score: 0.76 · 2026-04-21

Related Research

Hypotheses and analyses mentioning M6A MODIFICATION in their description or question text

No additional research found