The discovery of 'smoldering CALD' with low NfL contradicts the expected correlation between demyelination severity and NfL levels. This paradox suggests unknown disease mechanisms that could represent distinct therapeutic targets or require different monitoring approaches. Gap type: contradiction Source paper: Neurofilament light chain as a potential biomarker for monitoring neurodegeneration in X-linked adrenoleukodystrophy. (2021, Nature communications, PMID:33753741)
Landscape Summary: Why do some CALD patients exhibit atypically low NfL despite ongoing myelin destruction? is a 0.78 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Why do some CALD patients exhibit atypically low NfL despite ongoing myelin destruction? — INVOKE-2 (completed)
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