gene

NFL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

302Connections

19Hypotheses

30Analyses

50Outgoing

50Incoming

Summary

NFL is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, therapeutic target. Associated with ALS, Aging, Als. Connected to 169 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NEFL
Full Name	Neurofilament Light Polypeptide
Chromosome	8p21.2
Function	These dimers associate in an antiparallel, staggered manner to form tetramers, which then laterally associate into protofilaments and mature 10-nm intermediate filaments.
Primary Expression	Motor Neurons, Cortical Neurons, Peripheral Nerves, All Neurons (ubiquitous)
Molecular Weight	~61 kDa (native), ~10 kDa (fragments in blood)
Amino Acids	543 aa
Exons	4
Pathways	Axonal Transport
UniProt ID	P07196
NCBI Gene ID	4747
Ensembl ID	ENSG00000277586
OMIM	162280
GeneCards	NEFL
Human Protein Atlas	NEFL
Associated Diseases	Alzheimers_disease
Interactions	STMN2, PVALB, RANK, CNR1, STATHMIN, NRGN
KG Connections	200 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NFL — AlphaFold P07196 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Pathway Diagram

graph TD
    NFL["NFL"]
    NFL -.biomarker for.-> Neurodegeneration["Neurodegeneration"]
    NFL -.biomarker for.-> Neuroinflammation["Neuroinflammation"]
    NFL -.biomarker for.-> Inflammation["Inflammation"]
    NFL -.biomarker for.-> Als["Als"]
    NFL -.biomarker for.-> Aging["Aging"]
    NFL -.biomarker for.-> Alzheimer["Alzheimer"]
    NFL -->|"target for"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    NFL -->|"target for"| Ms["Ms"]
    UCHL1["UCHL1"] -->|"interacts"| NFL
    GFAP["GFAP"] -->|"interacts"| NFL
    TMEM119["TMEM119"] -->|"interacts"| NFL
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -.biomarker for.-> NFL
    BACE1["BACE1"] -.biomarker for.-> NFL
    SOD1["SOD1"] -.protects against.-> NFL
    APOE4["APOE4"] -->|"activates"| NFL
    ALS["ALS"] -.biomarker for.-> NFL
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"target for"| NFL
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -.biomarker for.-> NFL

Outgoing (194)

Target	Relation	Type	Str
Als	biomarker_for	disease	1.00
Alzheimer	biomarker_for	disease	1.00
Dementia	biomarker_for	disease	1.00
ALZHEIMER'S DISEASE	biomarker_for	gene	1.00
Neurodegeneration	biomarker_for	disease	0.95
Als	associated_with	disease	0.95
GFAP	biomarker_for	gene	0.90
DEMENTIA	biomarker_for	gene	0.90
Neuronal Injury	biomarker_for	mechanism	0.85
Aging	biomarker_for	disease	0.85
Aging	associated_with	disease	0.85
Inflammation	associated_with	disease	0.75
Neuroinflammation	biomarker_for	disease	0.75
Alzheimer	associated_with	disease	0.75
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.75
Als	activates	disease	0.75
Neurodegeneration	associated_with	disease	0.75
Neuropathy	associated_with	disease	0.75
GFAP	associated_with	gene	0.70
NEUROINFLAMMATION	biomarker_for	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
Dementia	associated_with	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	biomarker_for	disease	0.65
Ms	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	protects_against	disease	0.65
Als	protects_against	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	biomarker_for	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Tauopathy	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Traumatic Brain Injury	causes	disease	0.65
ALS	causes	disease	0.65
ALS	biomarker_for	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Als	implicated_in	disease	0.65
Neurodegeneration	implicated_in	disease	0.65

Incoming (108)

Source	Relation	Type	Str
TAU	biomarker_for	gene	1.00
ALZHEIMER	biomarker_for	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	0.90
AMYLOID	biomarker_for	gene	0.90
ALS	biomarker_for	gene	0.80
NEURODEGENERATION	biomarker_for	gene	0.80
TAU	associated_with	gene	0.74
NEURODEGENERATION	associated_with	gene	0.74
TAU PATHOLOGY	biomarker_for	gene	0.70
ALZHEIMER	associated_with	gene	0.70
UCHL1	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
TMEM119	interacts_with	gene	0.60
SYNAPTOPHYSIN	biomarker_for	gene	0.60
BACE1	biomarker_for	gene	0.60
SOD1	associated_with	gene	0.60
SOD1	protects_against	gene	0.60
APOE4	activates	gene	0.60
GFAP	associated_with	gene	0.60
MAPT	inhibits	gene	0.60
TMEM106B	interacts_with	gene	0.60
C9ORF72	inhibits	gene	0.60
GRN	inhibits	gene	0.60
EGFR	associated_with	gene	0.60
GAIN	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
MAX	therapeutic_target	gene	0.60
DES	biomarker_for	gene	0.60
HTT	interacts_with	gene	0.60
GFAP	biomarker_for	gene	0.60
NEUROGRANIN	biomarker_for	gene	0.60
APOE	activates	gene	0.60
IL10	activates	gene	0.60
IL18	activates	gene	0.60
TNF	activates	gene	0.60
IL6	activates	gene	0.60
UBIQUITIN	biomarker_for	gene	0.60
GR	expressed_in	gene	0.60
GR	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
ALZHEIMER DISEASE	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
AMYLOID-BETA	associated_with	gene	0.60
SLEEP-WAKE CYCLE	biomarker_for	gene	0.60
FTLD	associated_with	gene	0.60
HEXANUCLEOTIDE REPEAT EXPANSIONS	associated_with	gene	0.60
ASTROCYTES	biomarker_for	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60

Targeting Hypotheses (19)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone	0.645	neurodegeneration	What are the precise temporal dynamics o
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam	0.617	neurodegeneration	What are the mechanisms by which gut mic
STING Antagonism Prevents Acute-to-Chronic Neuroinflammation	0.605	neuroinflammation	What molecular mechanisms drive the tran
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.601	neurodegeneration	What are the mechanisms by which gut mic
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.599	neurodegeneration	What are the mechanisms by which gut mic

Microbial Inflammasome Priming Prevention	0.584	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N	0.582	neurodegeneration	What are the mechanisms by which gut mic
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.581	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu	0.580	neurodegeneration	What are the mechanisms by which gut mic
PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocyte	0.576	neuroinflammation	How do oligodendrocytes initiate neuroin
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A	0.512	neurodegeneration	What are the mechanisms by which gut mic
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.499	neuroinflammation	Why do TAM receptors protect against neu
GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R	0.498	neuroinflammation	Why do TAM receptors protect against neu
Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio	0.486	translational neuroscience	Which metabolic biomarkers can distingui
Cardiovascular-Neuroinflammatory Dual Targeting	0.462	neurodegeneration	Neuroinflammation and microglial priming
Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha	0.452	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinf	0.444	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
Cardiovascular-Neuroinflammation Crosstalk Interruption	0.437	Alzheimer's disease	Neuroinflammation and microglial priming
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro	0.424	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Systemic inflammation as a central player in the initiation and development of A [PMID:40841660]	Bayraktaroglu I, Ortí-Casañ N, Van Dam D	Immunity & ageing : I & A	2025	1
USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990]	["Di Q", "Zhao X", "Tang H", "Li X", "Xi	Autophagy	2023	1
USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradatio [PMID:34486483]	["Cai B", "Zhao J", "Zhang Y", "Liu Y",	Autophagy	2022	1
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861]	["Han X", "Sun S", "Sun Y", "Song Q", "Z	Autophagy	2020	1
Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's di [PMID:41747877]	Waghmare A, Rahangdale S, Khare K, Taksa	Molecular and cellular neurosc	2026	0
The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436]	Gopalakrishna PK, Che Mohd Nassir CMN, A	Cellular and molecular neurobi	2026	0
Elevated expression of the NLRP3 inflammasome in post-mortem brain white matter [PMID:41687275]	Otálora-Alcaraz A, Sun MC, Hofman N, Cos	Multiple sclerosis and related	2026	0
NLRP3 Inflammasome and Polycystic Ovary Syndrome (PCOS): A Novel Profile in Adip [PMID:41596350]	Alenezi SA, Alshammari K, Khan R, Amer S	International journal of molec	2026	0
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PK [PMID:40659086]	Li Z, Tan D, Lin J, Zhang T, Liu B et al	J Adv Res	2026	0
Celastrol treatment attenuates the inflammatory response in Alzheimer's disease [PMID:40762111]	Cao F, Zhang P, Zheng Z, Wang P, Wang Y	Neurol Res	2026	0
CircCramp1l targets the miR-532-3p/HMGB1/Drp1 axis to regulate allergic rhinitis [PMID:41519399]	Zhang Y, Wang J, Song Y, Chai J, Li L et	Biochem Pharmacol	2026	0
Panax ginseng-derived Exosome-like Nanoparticles Prevent LPS-induced Septic Shoc [PMID:41530048]	Kim Y, Kim YK, Lee S, Kim M, Lee SW et a	Mol Pharm	2026	0
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026	0
2'-Fucosyllactose Alleviates Metabolic Hypertension in Mice via Gut Microbiota M [PMID:41926238]	Chen J, Liang S, Liu D, Yang S, Yan Q et	J Agric Food Chem	2026	0
Leveraging intraperitoneal delivery of toll-like receptor agonists to treat peri [PMID:41926324]	Yan H, Chia D, Ernst S, Demuytere J, Cos	Expert Opin Drug Deliv	2026	0
Small-molecule PCSK9 inhibition enhances BBB amyloid-β clearance and suppresses [PMID:41927877]	Miao J, Wang J, Zhou W, Guo J	Sci Rep	2026	0
Anti-carbamylated protein antibodies stabilize carbamylated Histone H3 to promot [PMID:41930627]	Nakabo S, Hanata N, Patino-Martinez E, H	Arthritis Rheumatol	2026	0
In silico design of a novel multi-epitope mRNA vaccine candidate for BtHKU5-CoV- [PMID:41931545]	Zheng N, Xu Y	PLoS Negl Trop Dis	2026	0
Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF. [PMID:41931597]	Ma B, Lyu W, Rizk J, Han X, Kjær M et al	Sci Immunol	2026	0

NFL

Understanding Entity Pages

Summary

Wiki Pages (21)

Neurofilament Light Chain (NfL) in Blood - Biomarker

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

Atypical Parkinsonism

CBS/PSP Rehabilitation Master Guide

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

nimodipine-als

Therapeutics

PI-2620 Tau PET in PSP

Pathway Diagram

Outgoing (194)

Incoming (108)

Targeting Hypotheses (19)

Mentioning Analyses (30)

What molecular mechanisms drive the transition from acute to persistent neuroinf

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

What molecular mechanisms underlie the dose-dependent protective effects of the

What are the specific molecular mechanisms by which peripheral monocytes cross t

What is the relative contribution of connexin-43 gap junctions vs tunneling nano

Extracellular vesicle biomarkers for early AD detection

Does human glymphatic function show clinically relevant circadian variation like

Is HCN1 dysfunction causal or protective in EC layer II neurodegeneration?

What is the actual quantitative contribution of FcRn-mediated transcytosis to BB

Is C1q elevation in AD pathogenic or compensatory for amyloid clearance?

Do oligodendrocytes require DNA repair enhancement or inhibition for neuroprotec

Is myelin loss in AD causal or an adaptive response to neuronal damage?

Can TREM2 receptor switching from agonism to antagonism be achieved safely witho

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Which specific metabolic pathways in APOE4 microglia are causally linked to dysf

Does tau aggregation specifically cause PS externalization in living cells versu

Do different priming stimuli create distinct chromatin landscapes or converge on

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Why do clinical manifestations overlap despite distinct underlying etiologies in

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

Why do systemic anti-inflammatory drugs fail in AD despite cardiovascular effica

Can circadian interventions reverse microglial priming independent of sleep disr

How do host cell factors influence the conformation and propagation properties o

What determines organelle-specific autophagy selectivity in neurodegenerative di

What are the specific pathophysiological mechanisms underlying uncommon immune-m

What specific astrocyte-derived factors can 'erase' pathological microglial memo

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

Related Papers (20)