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Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.
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ID: paper-26895297
📄 Paper Details
Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.
["Su\u00e1rez-Calvet M", "Neumann M", "Arzberger T", "Abou-Ajram C", "Funk E", "Hartmann H", "Edbauer D", "Kremmer E", "G\u00f6bl C", "Resch M"]
Abstract
Deposition of the nuclear DNA/RNA-binding protein Fused in sarcoma (FUS) in cytosolic inclusions is a common hallmark of some cases of frontotemporal lobar degeneration (FTLD-FUS) and amyotrophic lateral sclerosis (ALS-FUS). Whether both diseases also share common pathological mechanisms is currently unclear. Based on our previous finding that FUS deposits are hypomethylated in FTLD-FUS but not in ALS-FUS, we have now investigated whether genetic or pharmacological inactivation of Protein argini...
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📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
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Outgoing
1
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0 contradicting
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