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HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis.
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ID: paper-41023273
📄 Paper Details
HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis.
Mitchell CD, Morris CA, Wild M, Cunningham A, Chuesiang P et al.
Abstract
Pathological retinal neovascularization (NV) contributes to vision loss in diabetic retinopathy (DR) and retinopathy of prematurity, which are the leading causes of blindness in working-age adults and children, respectively. Retinal hypoxia is a key driver of pathological neovascularization that results in uncontrolled vessel sprouting and the formation of immature and leaky blood vessels. Anti-vascular endothelial growth factor and laser therapies are the standard of care to mitigate vision los...
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