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LC-MS profiling of
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ID: paper-41756837
📄 Paper Details
LC-MS profiling of
["Basirattalab A", "Wallis D", "Hartel N", "Jalalifarahani M", "Phillips C", "Graham N"]
Abstract
Although protein arginine methylation regulates diverse biological processes, it remains understudied relative to other post-translational modifications. Here, we analyzed C. elegans prmt-1 and prmt-5 null mutants using LC-MS proteomics to map PRMT methylation substrates and to quantify the effects of PRMT knockout on global protein abundance. High-pH strong cation exchange fractionation was used to enrich methylated peptides, and parallel analysis of whole cell lysates was used to measure globa...
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