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Fig. 3 — Potent and specific MTH1 inhibitors targeting gastric cancer.
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Created: 2026-04-21T18:29:40
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Fig. 3Figure 3
The cytotoxicities of compounds MI-743 and MI-929 on 16 cancer cell lines. a Four normal cell lines and above reported cancer cell lines were treated with different concentrations of MI-743 and MI-929 for 72 h. Cell viability was determined by MTT assay, using DMSO-treated controls. IC 50 values are indicated as the means ± SD of three independent experiments. TH588 and (S)-crizotinib were used as positive control. b The colony formations of MGC-803, HGC-27 and GES-1 cells were determined after being treated with 0.5, 2, 4, 8 and 10 µM of compound MI-743. At least three independent experiments were performed for each group. c , d Clonogenic survival rates of gastric cancer cell lines after MI-743 and MI-929 treatments were determined by measuring the absorbance values at 595 nm in relation to DMSO-treated controls. TH588 and (S)-crizotinib were used as positive control. Data are presented as means ± SD. Three individual experiments were performed for each group. * P < 0.05, **
▸Metadata
| pmid | paper-18d2a490986a |
| caption | The cytotoxicities of compounds MI-743 and MI-929 on 16 cancer cell lines. a Four normal cell lines and above reported cancer cell lines were treated with different concentrations of MI-743 and MI-92 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC6547740/bin/41419_2019_1665_Fig3_HTML.jpg |
| paper_title | Potent and specific MTH1 inhibitors targeting gastric cancer. |
| figure_label | Fig. 3 |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
📊 Evidence Profile
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+0%
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