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Fig. 6 — Potent and specific MTH1 inhibitors targeting gastric cancer.
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Created: 2026-04-21T18:29:40
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Fig. 6Figure 6
The anti-proliferative activity of MI-743 on gastric cancer xenografts. Gastric cancer cells MGC-803 were transplanted subcutaneously to the right side of BALB-C nude mice. When most of the tumor volumes reached 100 mm 3 , the mice were treated with oil or compound MI-743(40 mg/kg, once a day) for 25 days. a The average tumor weight. b The tumor volumes were measured every 4 days. ( c ) The mice body weights were measured every 2 days. d , e The tumor tissues were collected and fixed in 4% buffered paraformaldehyde and paraffin-embedded for immunohistochemistry to detect the protein level of 8-oxo-dG and ATMpS1981 ( e ), H&E staining to observe the cell morphology and TUNEL staining to examine apoptosis status ( d ). Pictures for immunohistochemistry and H&E staining were originally captured at ×200 and ×400 magnification. Pictures for TUNEL staining were originally captured at ×400 magnification. f The mice major organs were collected and fixed in 4% buffered paraformaldehyde
▸Metadata
| pmid | paper-18d2a490986a |
| caption | The anti-proliferative activity of MI-743 on gastric cancer xenografts. Gastric cancer cells MGC-803 were transplanted subcutaneously to the right side of BALB-C nude mice. When most of the tumor volu |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC6547740/bin/41419_2019_1665_Fig6_HTML.jpg |
| paper_title | Potent and specific MTH1 inhibitors targeting gastric cancer. |
| figure_label | Fig. 6 |
| figure_number | 6 |
| _schema_version | 1 |
| source_strategy | pmc_api |
📊 Evidence Profile
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