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Fig. 3 — Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differe
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Created: 2026-04-21T18:29:40
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Fig. 3Figure 3
A: Histogram of the most abundant proteins measured in astrocyte ApoE lipoproteins. Abundance was determined by excluding common contaminants, showing differential expression compared to proteins measured in ApoE −/− astrocyte-conditioned media, and the protein abundance being greater than the total mean + 0.5 standard deviation threshold. Error bars represent mean ± SEM. For proteomics analysis, the following groups were analyzed: ApoE2 astrocytes (n = 5), ApoE3 astrocytes (n = 5), and ApoE4 astrocytes (n = 5). B: PCA of the proteome of astrocyte ApoE lipoproteins. Circles are colored based on the ApoE isoform and represent the 95% confidence interval. Astrocyte samples largely overlap in their proteome, suggesting that the ApoE isoform is not a major determinant of the proteome of astrocyte-secreted ApoE lipoproteins. C: Volcano plot showing differential protein abundance of proteins bound to astrocyte ApoE2 immunopurified lipoproteins versus astrocyte ApoE3 immunopurified lipoprote
▸Metadata
| pmid | paper-41692246 |
| caption | A: Histogram of the most abundant proteins measured in astrocyte ApoE lipoproteins. Abundance was determined by excluding common contaminants, showing differential expression compared to proteins meas |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12996666/bin/gr3.jpg |
| paper_title | Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform. |
| figure_label | Fig. 3 |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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