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Figure 2 — TFE3-Rearranged and TFEB-Altered Renal Cell Carcinomas: Molecular Landscape and
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Created: 2026-04-21T18:29:40
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ID: paper-fig-paper-41899560-2
Figure 2Figure 2
Multistep and multiscale model of MiT family-driven renal cell carcinoma. Schematic overview linking initiating genetic events ( TFE3 gene fusions or TFEB gene amplification/rearrangement) to MiT-driven transcriptional reprogramming, cellular consequences, characteristic morphologic patterns, and downstream clinical implications. The diagram integrates molecular alterations with diagnostic pitfalls, clinical heterogeneity, and current therapeutic uncertainty. Arrows indicate progression/relationships between molecular alterations, cellular consequences, tumor phenotype, and clinical implications; colors and icons are schematic and not quantitative. Created in BioRender. Cotaina Recio, M. (2026) https://BioRender.com/8vz33mn (accessed on 12 March 2026).
▸Metadata
| pmid | paper-41899560 |
| caption | Multistep and multiscale model of MiT family-driven renal cell carcinoma. Schematic overview linking initiating genetic events ( TFE3 gene fusions or TFEB gene amplification/rearrangement) to MiT-d |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC13025244/bin/cancers-18-00958-g002.jpg |
| paper_title | TFE3-Rearranged and TFEB-Altered Renal Cell Carcinomas: Molecular Landscape and Therapeutic Advances. |
| figure_label | Figure 2 |
| figure_number | 2 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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