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Fig. 3 — C1q propagates microglial activation and neurodegeneration in the visual axis fo
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Created: 2026-04-21T18:29:40
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Fig. 3Figure 3
Activation and increased cell populations of macroglia and microglia in the retina post I/R. Representative images of Iba1- and GFAP-positive cells in uninjured ( a ), ( c ) and ischemic ( b ), ( d ) retinas. a , b Yellow inset boxes of selected Iba1 + microglia demonstrate morphological differences between senescent (i) and activated (ii) cellular states. c , d Morphological differences observed in GFAP + cells following ischemia. Astrocytes and Müller cells display elongated processes extending through the layers of the retina in addition to thickened cell bodies present in the GCL and NFL. e , f Thresholding analysis based upon percent area of retina occupied was applied to determine changes in cell density. Microglial density ( e ) was significantly increased in ischemic retinas at all time points quantified compared with uninjured controls. Density of macroglia ( f ) trended upward on day 3 and was statistically significant at all time points measured thereafter. Mean ±
▸Metadata
| pmid | paper-828b7c4fa9a6 |
| caption | Activation and increased cell populations of macroglia and microglia in the retina post I/R. Representative images of Iba1- and GFAP-positive cells in uninjured ( a ), ( c ) and ischemic ( b ), ( d ) |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC4806521/bin/13024_2016_89_Fig3_HTML.jpg |
| paper_title | C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury. |
| figure_label | Fig. 3 |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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