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Fig. 6 — C1q propagates microglial activation and neurodegeneration in the visual axis fo
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Fig. 6Figure 6
C1qa -deficiency mitigates loss of RGCs using two independent assays of cell counts 28 days following retinal I/R. ( a ) H&E stained and ( c ) Rbpms-immunolabeled retinal cross sections used to assess RGC loss between uninjured controls and three C1qa genetic backgrounds receiving ischemic injury. ( b ) Quantification of nuclei counted in the GCL determined there was a significant loss of cells ( p < 0.01) in WT retinas but not in the C1qa -deficient retinas compared to control. ( d ) Counts of Rbpms + RGCs displayed a statistically significant loss ( p < 0.01) in ischemic eyes of WT mice compared to controls. No statistical differences were determined in ischemic retinas of C1qa
+/− or C1qa
−/− animals. However, a statistical difference ( p < 0.01) was measured when C1qa
−/− retinas were compared to WT. Mean ± SEM, n = 7 per group. ** p < 0.01 compared to control and ## p < 0.01 compared to WT – I/R determined by One-way ANOVA followed by Holm-Sidak post test. S
▸Metadata
| pmid | paper-828b7c4fa9a6 |
| caption | C1qa -deficiency mitigates loss of RGCs using two independent assays of cell counts 28 days following retinal I/R. ( a ) H&E stained and ( c ) Rbpms-immunolabeled retinal cross sections used to assess |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC4806521/bin/13024_2016_89_Fig6_HTML.jpg |
| paper_title | C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury. |
| figure_label | Fig. 6 |
| figure_number | 6 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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