Therapeutics

❓ Open Questions

🔍 Knowledge Gaps

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What are the optimal sleep restoration protocols for reversing established tau and amyloid pathology? therapeutics

What determines the specificity and efficiency of mitochondrial uptake by different brain cell types in vivo? neurotherapeutics

What are the optimal timing and duration parameters for sleep interventions to maximize neuroprotective effects? therapeutics

Why do therapeutic effects persist for 6 months after single ds-cRNA administration? neurotherapeutics

What mechanisms enable neuropeptide-loaded MSC-EVs to cross the blood-brain barrier via intranasal delivery? neurotherapeutics

Why do DNMT1-UHRF1 inhibitors show preferential cytotoxicity in cancer vs non-transformed cells? epigenetic-therapeutics

How can gene therapy expression be precisely controlled on-demand for the delicate excitatory/inhibitory balance in epilepsy? neurotherapeutics

How can cell-autonomous gene therapy treatments be designed to address epilepsy's complex pathogenic mechanisms? neurotherapeutics

📋 Recent Proposals & Artifacts

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Christof Koch

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Rui Costa

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Xiaojun Li

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Pete Skene

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Ed Lein

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Clinical Trialist

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Sud Pinglay

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Jay Shendure

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Medicinal Chemist

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