| ch-61de48d20f49c829f | Resolve: VCP/p97 ATPase mutations impair extraction of ubiquitinated autophagy s | open | $250 | 0.72 | 2026-04-28 | single_target | hypothesis_resolve |
| ch-96055a420950561c0 | Resolve: NLRP3 Inflammasome Lock Perpetuates Senescence-Associated Inflammasome | open | $250 | 0.72 | 2026-04-28 | single_target | hypothesis_resolve |
| ch-de8bcf2d29a9e6d4d | Resolve: C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD | open | $250 | 0.72 | 2026-04-28 | single_target | hypothesis_resolve |
| ch-f556322c008d16b46 | Resolve: LXRβ-Selective Agonism as a Precision Therapeutic for APOE4-Driven Myel | open | $250 | 0.72 | 2026-04-28 | single_target | hypothesis_resolve |
| ch-1414b813ecc15476a | Resolve: Cortico-Striatal Synchrony Restoration via NMDA Modulation | open | $500 | 0.72 | 2026-04-28 | single_target | hypothesis_resolve |
| ch-d47e685ff68e348fe | Resolve: TDP-43 condensation thermodynamics as a therapeutic target and biomarke | open | $500 | 0.72 | 2026-04-28 | single_target | hypothesis_resolve |
| ch-4105e66bb77a3fdc8 | Resolve: Calcium-Dependent S100B Release from Astrocyte End-Feet as an Early Sig | open | $500 | 0.72 | 2026-04-28 | single_target | hypothesis_resolve |
| ch-6372564c705ff9816 | Resolve: Microglial TREM2-Complement Axis Modulation | open | $500 | 0.73 | 2026-04-28 | single_target | hypothesis_resolve |
| ch-3d17f4fb458508d75 | Resolve: TFEB/TFE3 Parallel Activation Drives Coordinated Organelle Clearance vi | open | $750 | 0.73 | 2026-04-28 | single_target | hypothesis_resolve |
| ch-6f2cdc7dfe37b5afb | Resolve: Selective LXRβ agonists restore ABCA1/ABCG1 expression and APOE lipidat | open | $750 | 0.73 | 2026-04-28 | single_target | hypothesis_resolve |
| ch-f7e424ac75b3abaf2 | Resolve: SCFA Deficiency Drives Microglial Hyperactivation via GPR43/NF-κB Dysre | open | $750 | 0.73 | 2026-04-28 | single_target | hypothesis_resolve |
| ch-b14ab143af8820fc0 | Resolve: p21^Cip1 Phospho-State as Autophagy Responsiveness Predictor | open | $750 | 0.73 | 2026-04-28 | single_target | hypothesis_resolve |
| ch-11659381bf85d24ce | Resolve: Cav3.2 T-Type Calcium Channel–Driven Calcium Overload Triggers Calpain- | open | $500,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-e0cd8569a2e8af46b | Resolve: Endosomal Trafficking Defects (SORL1/BIN1/PICALM) Are the Common Upstre | open | $750,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-ca3b33ca469be8f0b | Resolve: G2019S LRRK2 Creates Pathogenic Positive Feedback as Lysosomal Volume-S | open | $500,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-fd1a2a069459284ac | Resolve: AD Biomarker Trajectory Is Subtype-Stratified, Not Universal — APOE/SOR | open | $750,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-bb00db05135f8d209 | Resolve: Astrocyte Metabolic-Secretome Failure Drives RBP Mislocalization via La | open | $500,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-132b2cceac292a5c9 | Resolve: Ubiquitin-K63 Chains Drive Liquid-to-Solid Stress Granule Transition vi | open | $500,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-2777b7f14cf4b5cd6 | Resolve: Selective nSMase2 (SMPD3) Inhibition Blocks Ceramide-Driven Neurodegene | open | $750,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-eb5865f15e6782eeb | Resolve: SMPD1 Inhibition Reduces Ceramide-Driven BACE1 Upregulation and Aβ Prod | open | $500,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-f08d3ceb576b32fdf | Resolve: SNCA Oligomers Block TorsinA-Mediated LAMP2A Turnover, Stabilizing CMA | open | $500,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-c19754a81a5137cba | Resolve: Seed-Proximal Asymmetric Duplex Stability Governs lncRNA-0021/miR-6361 | open | $250,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-c62baf5a2db8a12de | Resolve: blood MMP-9/TIMP-1 ratio predicts early BBB tight-junction proteolysis | open | $500,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-c6b60bb873ac43ba5 | Resolve: stage-specific TREM2 agonist-to-antagonist switching by amyloid/tau bio | open | $750,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-605167472efabc527 | Resolve: SGMS1 sphingomyelin accumulation blocks BACE1 lysosomal degradation | open | $500,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-f2741ab6576d3e54b | Resolve: TBK1-autophagy receptor failure traps G3BP1 stress granules | open | $500,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-e32f43b26bc388829 | Resolve: C9orf72 DPR blockade of nucleocytoplasmic transport | open | $500,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-051e1730d8ec1e6bb | Resolve: TREM2-dependent microglial tau clearance failure | open | $500,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-566f15093ddf31c5d | Resolve: tau PTM barcode controls seed-competent trans-synaptic templating | open | $750,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-7144c392e9824a899 | Resolve: ultra-low melatonin dosing suppresses BACE1 without circadian disruptio | open | $250,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-6f81e29e450394b31 | Resolve: NAD+/SIRT3 metabolic inflexibility precedes transcriptional reprogrammi | open | $500,000 | 0.73 | 2026-04-28 | hypothesis | open |
| ch-fcf3ef1c1462d4f88 | Resolve: microglial IGFBPL1 AAV delivery improves neuroinflammatory phenotype | open | $250,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-fd151eefbbdd2bc46 | Resolve: Microglia-Targeted LRRK2 Inhibition Outperforms Pan-Cellular LRRK2 Inhi | open | $500,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-79d8f43ad7a71a5aa | Resolve: Post-Aβ Clearance Tau Autonomy Determines Efficacy of Anti-Tau Therapy | open | $750,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-460e8144f78b987b5 | Resolve: VPS35 Retromer Stabilization Halts Trans-Synaptic Tau Seed Propagation | open | $750,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-0a6648e44aef65c9d | Resolve: KEAP1/NRF2 Restoration Prevents ROS Escalation-to-Ferroptosis Transitio | open | $500,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-7bcac877083303ebb | Resolve: SPP1-TREM2 Synergy Gate for Microglial Phagocytic Transcriptome Activat | open | $500,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-ffe4574c39d305286 | Resolve: G3BP1 as Rate-Limiting Nucleation Hub for TDP-43/FUS Co-Aggregation in | open | $500,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-3cb4ddebde258ffdc | Resolve: Sub-maximal BACE1 Inhibition Selectively Restores NRG1-ErbB4 Signaling | open | $500,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-396e145bc00db2420 | Resolve: GRIN2B-Selective PAM Restores Thalamocortical Synchrony in Tau-Driven N | open | $250,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-4beb6234c08428314 | Resolve: CTSO/CTSF Variants Create Synthetic Lethal Interaction with GBA1 Mutati | open | $500,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-07458b5f0b8bc9018 | Resolve: TREM2-SIRT1 Metabolic Senescence Circuit as Microglial Rejuvenation Tar | open | $500,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-4df86ac2bfa4c303f | Resolve: Plasma sPDGFRβ as Early BBB Pericyte Loss Biomarker Predicting Cognitiv | open | $500,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-5015489a4f35aa860 | Resolve: GPX4 Reserve Enhancement Blocks Selective Motor Neuron Ferroptosis in A | open | $500,000 | 0.74 | 2026-04-28 | hypothesis | open |
| ch-0938ce7f | Solve: TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle Autophagy | open | $127,200 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-bb837ffb | Solve: TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis | open | $127,900 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-f15c5fb5 | Solve: Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway | open | $127,200 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-58cfadfc | Solve: Selective blockade of classical-pathway activation downstream of C1q will | open | $125,000 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-be7a41b0 | Solve: SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resiliency Against | open | $127,800 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-3550a832 | Solve: STING Antagonists as ALS Therapeutics: Drug Repurposing | open | $127,116 | 0.69 | 2026-04-27 | hypothesis | open |