| ch-2a6b6d4d | Solve: Tau/MAP6 ratio as a master switch for microtubule dynamics plasticity | open | $125,000 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-411adaea | Solve: APOE4 astrocytes exhibit impaired cholesterol efflux via ABCA1/ABCG1 tran | open | $125,772 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-468646af | Solve: Kinetic Modeling Predicts Threshold-Dependent Efficacy—Early Intervention | open | $126,526 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-da1420ed | Solve: sTREM2 as Biomarker of Cystatin-C Therapeutic Efficacy | open | $125,663 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-5e6d354b | Solve: Test: TREM2 enhances amyloid clearance | open | $125,500 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-b28459fa | Solve: Closed-loop transcranial focused ultrasound to restore hippocampal gamma | open | $126,658 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-2f331d72 | Solve: NLRP3 Inhibition (H7): Downstream Inflammatory Reversal | open | $128,000 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-31844289 | Solve: Differential Complement Regulator Expression on Synaptic Membranes (CD55/ | open | $128,316 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-494c8a0f | Solve: Complement C1q-Mediated Synaptic Pruning Drives Early Cognitive Decline i | open | $126,900 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-baf530e6 | Solve: HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA Prevention | open | $126,600 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-44c2c9d3 | Solve: METTL3-Mediated m6A Modification of lncRNA-0021 Regulates miR-6361 Seques | open | $125,883 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-35e9cdcd | Solve: Synaptic Vesicle Cycle Hijacking: Shared Convergent Mechanism for α-Synuc | open | $126,000 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-f15c5fb5 | Solve: Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway | open | $127,200 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-718caa73 | Solve: Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Overexpression | open | $124,540 | 0.67 | 2026-04-27 | hypothesis | open |
| ch-0938ce7f | Solve: TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle Autophagy | open | $127,200 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-10254beb | Solve: H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from Epigenomic Hom | open | $127,000 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-988677fd | Solve: N-acetylcysteine (NAC) / System Xc⁻ - Mediated GSH Support for Neurovascu | open | $126,000 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-6d1c8f2b | Solve: GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Contact Sites by Reduci | open | $124,670 | 0.67 | 2026-04-27 | hypothesis | open |
| ch-e97a3612 | Solve: TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming | open | $124,836 | 0.67 | 2026-04-27 | hypothesis | open |
| ch-364fc7a4 | Solve: Dual-Circuit Tau Vulnerability Cascade | open | $127,425 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-9cc61413 | Solve: C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV Interneuron In | open | $124,700 | 0.67 | 2026-04-27 | hypothesis | open |
| ch-560ff61b | Solve: PARP1-NAD+-AIF bioenergetic collapse drives a self-amplifying parthanatos | open | $126,000 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-1dfcba32 | Solve: Oligodendrocyte Precursor Cell Senescence in White Matter Disease | open | $126,900 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-dfc2b184 | Solve: miR-33 Antisense Oligonucleotide Hyper-Lipidation Strategy | open | $127,449 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-b97a5f73 | Solve: Repeat-domain exposure defines seed-competent tau conformers | open | $126,000 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-b0435c04 | Solve: INPP5D (SHIP1) Inhibition to Shift Microglial Polarization | open | $125,800 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-73743972 | Solve: Exosomal SNCA Propagation from Lysosome-Compromised Neurons Contains a Di | open | $127,670 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-86eea32a | Solve: VHH-Fc Fusion Constructs with Separate BBB-Targeting Moiety | open | $125,000 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-2461d6f7 | Solve: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Substrate Pools | open | $127,600 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-aa26ebf6 | Solve: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Priming | open | $127,696 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-83dc1fcd | Solve: Alpha-gamma cross-frequency coupling enhancement to restore thalamo-corti | open | $127,482 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-59567d8f | Solve: Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Neuronal Tau Up | open | $127,220 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-f87fd509 | Solve: Circadian Clock-Autophagy Synchronization | open | $126,311 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-839d45de | Solve: Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modulation | open | $127,303 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-d809e59d | Solve: Biphasic Ketogenic Intervention Protocol | open | $127,325 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-0691b8e3 | Solve: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes U | open | $127,900 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-be7a41b0 | Solve: SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resiliency Against | open | $127,800 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-90d82f6f | Solve: CX3CR1-TREM2 Integration for Synapse Pruning Normalization | open | $127,600 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-4b558222 | Solve: APOE4-Specific Proteolytic Fragment Inhibition Therapy | open | $127,700 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-fd47d657 | Solve: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE Pe | open | $127,214 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-db4c2f9d | Solve: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in | open | $126,420 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-8c71a9f1 | Solve: Hypothesis 3: HepaCAM-Containing Extracellular Vesicles | open | $126,200 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-be0e369c | Solve: Enhancing Microglial Phagocytosis of Extracellular Tau via TREM2 Activati | open | $127,052 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-3550a832 | Solve: STING Antagonists as ALS Therapeutics: Drug Repurposing | open | $127,116 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-60e2e624 | Solve: GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9 Dopaminergic | open | $125,000 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-99580074 | Solve: Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate | open | $124,880 | 0.67 | 2026-04-27 | hypothesis | open |
| ch-9de0b376 | Solve: Therapeutic Window Exists Because Amplified Signals (Not Baseline) Drive | open | $128,000 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-402c630b | Solve: Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Cholinergic Signal | open | $126,900 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-fcd33968 | Solve: Lysosomal Cathepsin-Dependent Tau Clearance | open | $126,700 | 0.69 | 2026-04-27 | hypothesis | open |
| ch-bb837ffb | Solve: TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis | open | $127,900 | 0.70 | 2026-04-27 | hypothesis | open |