| ch-aa26ebf6 | Solve: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Priming | open | $127,696 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-4b558222 | Solve: APOE4-Specific Proteolytic Fragment Inhibition Therapy | open | $127,700 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-be7a41b0 | Solve: SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resiliency Against | open | $127,800 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-0691b8e3 | Solve: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes U | open | $127,900 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-58cfadfc | Solve: Selective blockade of classical-pathway activation downstream of C1q will | open | $125,000 | 0.68 | 2026-04-27 | hypothesis | open |
| ch-bb837ffb | Solve: TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis | open | $127,900 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-9de0b376 | Solve: Therapeutic Window Exists Because Amplified Signals (Not Baseline) Drive | open | $128,000 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-663f3498 | Solve: PINK1/Parkin–TREM2 Axis: Convergent Mitophagy Failure Unifies PD (SNCA/αS | open | $128,000 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-4d0793b5 | Solve: Sleep-Dependent Glymphatic Clearance Expands the Therapeutic Window by Re | open | $128,000 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-2f331d72 | Solve: NLRP3 Inhibition (H7): Downstream Inflammatory Reversal | open | $128,000 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-31844289 | Solve: Differential Complement Regulator Expression on Synaptic Membranes (CD55/ | open | $128,316 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-0a9223c0 | Solve: LAMP2A Liquid-Liquid Phase Separation Defects in Dopaminergic Neurons Cre | open | $128,330 | 0.70 | 2026-04-27 | hypothesis | open |
| ch-8e79f2ab | Solve: Exposed amyloidogenic segments (β-sheet propensity residues) serve as HSP | open | $129,004 | 0.71 | 2026-04-27 | hypothesis | open |
| ch-f62a2df8 | Solve: TIA1 Low-Complexity Domain Oxidation Drives Aberrant Stress Granule Assem | open | $131,000 | 0.73 | 2026-04-27 | hypothesis | open |
| ch-713ff450 | Solve: MATR3 Nuclear Body Disruption Impairs RNA Processing Hubs and Triggers Sp | open | $131,800 | 0.74 | 2026-04-27 | hypothesis | open |
| ch-cc150441 | Solve: GLE1-Mediated mRNA Export Defect Creates Translation-Competent mRNA Starv | open | $132,600 | 0.74 | 2026-04-27 | hypothesis | open |
| ch-b6fe1e70 | Solve: hnRNP A2/B1 Staufen2-Mediated Axonal RNA Granule Transport Failure Drives | open | $133,400 | 0.75 | 2026-04-27 | hypothesis | open |
| ch-822a9302 | Solve: ATM Kinase Hyperactivation Triggers DNA Damage Response Overflow and p53- | open | $134,200 | 0.76 | 2026-04-27 | hypothesis | open |
| ch-d3b137e0 | Solve: SFPQ Paralog Displacement Triggers Cryptic Polyadenylation and Global RNA | open | $135,000 | 0.77 | 2026-04-27 | hypothesis | open |
| ch-47f928f2 | Solve: RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA Processing Con | open | $135,800 | 0.77 | 2026-04-27 | hypothesis | open |
| ch-cb760956 | Solve: eIF2α Phosphorylation Imbalance Creates Integrated Stress Response Overfl | open | $136,600 | 0.78 | 2026-04-27 | hypothesis | open |
| ch-c12bd8d725350f7d9 | Resolve: Glucosylceramide Accumulation Disrupts SNX5-Mediated Retromer Sorting | open | $250 | 0.81 | 2026-04-27 | hypothesis | open |
| ch-7bac9dfb0d038e1ff | Resolve: Lysosomal Acidification Failure via GBA1/LAMP2A Autophagy Convergence | open | $500 | 0.82 | 2026-04-27 | hypothesis | open |
| ch-1c98edef84f77dafe | Resolve: NMN/NAD+ Restoration for Cortical Neuron Senescence Rescue in AD | open | $500 | 0.82 | 2026-04-27 | hypothesis | open |
| ch-974fca5bbfd0f6385 | Resolve: Dasatinib+Quercetin Senolytic Clearance of p16Ink4a-High Neurons | open | $500 | 0.82 | 2026-04-27 | hypothesis | open |
| ch-0b94c4b5a48f4cdc1 | Resolve: mTORC1-TFEB Lysosomal Signaling Axis for Autophagy Restoration | open | $500 | 0.83 | 2026-04-27 | hypothesis | open |
| ch-70e7f9e2f9769eb5b | Resolve: DRP1/MFN2 Mitochondrial Dynamics Imbalance in Neurodegeneration | open | $500 | 0.83 | 2026-04-27 | hypothesis | open |
| ch-2600607c19253fff8 | Resolve: SASP Suppression vs. Senolytic Elimination — Optimal Therapeutic Strate | open | $500 | 0.84 | 2026-04-27 | hypothesis | open |
| ch-2b8edbe66eb2f1b10 | Resolve: Metabolic Checkpoint Failure in NG2+ Oligodendrocyte Progenitor Cells | open | $500 | 0.84 | 2026-04-27 | hypothesis | open |
| ch-54d20c5978fc57d5c | Resolve: Caloric Restriction Mimetic Combination for Neurodegeneration | open | $750 | 0.85 | 2026-04-27 | hypothesis | open |
| ch-3e5714ae1a13e2f34 | Resolve: Partial Cellular Reprogramming via Modified Yamanaka Cocktail | open | $750 | 0.85 | 2026-04-27 | hypothesis | open |
| ch-7fa858097c3d | Resolve: CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identifi | open | $5 | 0.80 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-0ae248919e55 | Resolve: TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, F | open | $5 | 0.80 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-1c9a3169b993 | Resolve: Integrated Biomarker Panel for Therapeutic Window Identification | open | $5 | 0.78 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-677a94a5dc90 | Resolve: Closed-loop transcranial focused ultrasound targeting CA1 PV interneuro | open | $5 | 0.80 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-cd6293969a50 | Resolve: Targeting SASP-Complement Amplification Through HIF-1α Downstream Effec | open | $5 | 0.79 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-5eda08b20963 | Resolve: Excitatory Neuron Synaptic Dysfunction and Mitochondrial Stress via MAP | open | $5 | 0.79 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-df852fecc077 | Resolve: NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic Axis and Dop | open | $5 | 0.79 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-661cdf0310f8 | Resolve: VCP-Mediated Autophagy Enhancement | open | $5 | 0.79 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-94a65f0b5f21 | Resolve: ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Mat | open | $5 | 0.80 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-af7acd405cb6 | Resolve: pH-Sensitive Bispecific Antibody Targeting Transferrin Receptor for CNS | open | $5 | 0.80 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-ffc4a9cfa9748625e | Resolve: TREM2-mediated microglial tau clearance enhancement | open | $250 | 0.78 | 2026-04-26 | single_hypothesis | hypothesis_resolve |
| ch-e810e5b66860cbf86 | Resolve: Closed-loop tACS targeting entorhinal cortex layer II SST interneurons | open | $250 | 0.78 | 2026-04-26 | single_hypothesis | hypothesis_resolve |
| ch-923b76d796607ba72 | Resolve: Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbates Amyloid P | open | $250 | 0.79 | 2026-04-26 | single_hypothesis | hypothesis_resolve |
| ch-69dc8b2a4c5dc1d02 | Resolve: G2019S primarily raises baseline LRRK2 kinase activity rather than ampl | open | $250 | 0.79 | 2026-04-26 | single_hypothesis | hypothesis_resolve |
| ch-8486067178a5d41ae | Resolve: Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling | open | $250 | 0.79 | 2026-04-26 | single_hypothesis | hypothesis_resolve |
| ch-f662c31c4dee32f93 | Resolve: Microglial TREM2-SYK Pathway Enhancement | open | $500 | 0.80 | 2026-04-26 | single_hypothesis | hypothesis_resolve |
| ch-badf8c6489f6f41b9 | Resolve: Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective Effector | open | $500 | 0.80 | 2026-04-26 | single_hypothesis | hypothesis_resolve |
| ch-b69b5151cd83eee47 | Resolve: TREM2 Deficiency Drives Microglial Senescence via Lipid Metabolism Dysr | open | $500 | 0.80 | 2026-04-26 | single_hypothesis | hypothesis_resolve |
| ch-902970258f4a13a40 | Resolve: 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Sel | open | $500 | 0.80 | 2026-04-26 | single_hypothesis | hypothesis_resolve |