SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽Demo🎬Demo VideoℹVision
← Pipeline / 🔍

Gaps

3,545 items
IdTitleStatusPriority ScoreComposite ScoreCreated AtDebate CountLast Debated AtDomain
gap-2026-lancet-demeImplementation gaps in the 2024 Lancet dementia prevention recommendations for uopen0.700.682026-04-280neurodegeneration
gap-2026-prion-protePrion protein species barrier mechanisms and their relevance to sporadic neuroderesolved0.680.662026-04-280neurodegeneration
gap-2026-sex-differeSex-specific adrenergic receptor mechanisms driving sex differences in Alzheimerresolved0.630.662026-04-280neurodegeneration
gap-2026-neu1-ppca-aNeu1 and PPCA lysosomal complex regulation of APP metabolism and amyloidogenesisopen0.700.682026-04-280neurodegeneration
gap-2026-s100a9-nlrpRetinal microglia S100A9-mediated NLRP3 inflammasome activation as a systemic inresolved0.620.642026-04-280neurodegeneration
gap-2026-dark-microgUltrastructural and molecular drivers of dark microglia formation in neurodegeneopen0.670.662026-04-280neurodegeneration
gap-2026-microbiome-Mechanistic pathways by which microbiome-based interventions influence neurodegeresolved0.650.682026-04-280neurodegeneration
gap-2026-ferroptosisIron-dependent protein aggregation cross-talk in Alzheimer's and Parkinson's disresolved0.720.682026-04-280neurodegeneration
gap-2026-peripheral-Peripheral-to-brain transport routes and tissue distribution of pathological neuopen0.680.652026-04-280neurodegeneration
gap-2026-abeta-a2v-vStructural basis for A2V protective versus A2T pathogenic effects on amyloid-betopen0.700.692026-04-280neurodegeneration
gap-2026-il8-neurotoIL-8 receptor network and downstream signaling mediating neurotoxicity in Alzheiresolved0.630.682026-04-280neurodegeneration
gap-2026-lrrk2-g2019LRRK2 G2019S regulation of clusterin and impaired astrocyte uptake of alpha-synuresolved0.650.672026-04-280neurodegeneration
gap-2026-peripheral-Mechanisms of peripheral alpha-synuclein preformed fibril transcytosis across thresolved0.720.682026-04-280neurodegeneration
gap-2026-trem2-aep-aTREM2-dependent microglial processing of alpha-synuclein fibrils via AEP truncatresolved0.680.692026-04-280neurodegeneration
gap-2026-dark-microgMechanistic chain from microglial ISR activation to toxic lipid secretion and syopen0.700.692026-04-280neurodegeneration
gap-20260427-221856What is the evidence for neuronal identity transcription factors as therapeutic investigating0.900.002026-04-270neurodegeneration
cgi-e4443e5acea5Unresolved cancer mechanism: Si xian formula (SXF) alleviates carboplatin-induceopen0.600.002026-04-270oncology-literature
cgi-16db8e844bb7Unresolved cancer mechanism: Sexual dimorphism and acute stress modulation of inopen0.600.002026-04-270oncology-literature
cgi-c7f5d4059dcbUnresolved cancer mechanism: Thrombospondin-1 triggers calreticulin expression iopen0.600.002026-04-270oncology-literature
cgi-feb3c858102dUnresolved cancer mechanism: NFYC upregulates KLF1 expression and activate LDHA open0.600.002026-04-270glioblastoma
cgi-49bb58434121Unresolved cancer mechanism: A neurotensin receptor type 1-derived pepducin actsopen0.600.002026-04-270oncology-literature
cgi-4e8b21a00bc7Unresolved cancer mechanism: FABP4 Couples Lipid Metabolism to PD-L1 Stabilizatiopen0.600.002026-04-270oncology-literature
cgi-825e00782510Unresolved cancer mechanism: A microbiota-derived bile acid overcomes antibioticopen0.600.002026-04-270oncology-literature
cgi-2c649a09fe23Unresolved cancer mechanism: Metabolic maintenance of breast cancer cells and meopen0.600.002026-04-270breast-cancer
cgi-14feadfb5af2Unresolved cancer mechanism: Cell fusion reprograms tumor cells and promotes RUNopen0.600.002026-04-270oncology-literature
cgi-bdfbc524531bUnresolved cancer mechanism: Sphingosine-1-Phosphate Receptor 3 Confers Tumor Meopen0.600.002026-04-270lung-cancer
cgi-329b401229eaUnresolved cancer mechanism: RTA‑408 induces p38‑dependent apoptosis and suppresopen0.600.002026-04-270oncology-literature
cgi-19b818b7e8a8Unresolved cancer mechanism: Vitexicarpin Directly Targets RSK2 to Attenuate Migopen0.600.002026-04-270breast-cancer
cgi-3cea00f6b48cUnresolved cancer mechanism: Microphthalmia/Transcription Factor E (MiT/TFE) Patopen0.600.002026-04-270oncology-literature
cgi-45bb77405774Unresolved cancer mechanism: Single-Cell Transcriptomics Reveals Immune Modulatiopen0.600.002026-04-270oncology-literature
cgi-780795b99a6cUnresolved cancer mechanism: Sorghum Promotes Cell Proliferation Through Activatopen0.600.002026-04-270oncology-literature
cgi-5b0b4190420dUnresolved cancer mechanism: High-Sugar Consumption Induces Anxiety-Like Behavioopen0.600.002026-04-270oncology-literature
cgi-9cb03e84a7cdUnresolved cancer mechanism: TRIM24 Regulates Adaptation to Glucose Deprivation open0.600.002026-04-270oncology-literature
cgi-a93d6c146194Unresolved cancer mechanism: Orally Administered Rhamnan Sulfate from Monostromaopen0.600.002026-04-270lung-cancer
cgi-47aaab3dbc2fUnresolved cancer mechanism: Integrative Multi-Omics Analysis Reveals HNRNPLL asopen0.600.002026-04-270oncology-literature
cgi-f5879cae7122Unresolved cancer mechanism: Reprogramming of the m(6)A Epitranscriptome Drives open0.600.002026-04-270oncology-literature
gap-methodol-2026042Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evaluaresolved0.920.002026-04-270neurodegeneration
gap-methodol-2026042Methodology challenge: dataset 'SEA-AD Differential Expression: AD vs Control (Mresolved0.920.002026-04-270neurodegeneration
gap-methodol-2026042Methodology challenge: dataset 'Allen Brain SEA-AD MTG 10x snRNA-seq' — evaluateresolved0.920.002026-04-270neurodegeneration
gap-methodol-2026042Methodology challenge: notebook 'Astrocyte reactivity subtypes in neurodegeneratresolved0.920.002026-04-270neurodegeneration
gap-methodol-2026042Methodology challenge: notebook 'Mitochondrial transfer between neurons and gliaresolved0.920.002026-04-270neurodegeneration
gap-methodol-2026042Methodology challenge: notebook 'Blood-brain barrier transport mechanisms for anresolved0.920.002026-04-270neurodegeneration
gap-synthetic-biologGap in Seattle Hub lineage tracing: Computational Lineage Reconstruction and Uncopen0.810.812026-04-260synthetic-biology-lineage-tracing
gap-synthetic-biologGap in Seattle Hub lineage tracing: Recording Neuroimmune and Degeneration-linkeopen0.830.832026-04-260synthetic-biology-lineage-tracing
gap-synthetic-biologGap in Seattle Hub lineage tracing: Spatial Lineage Atlases and Cross-platform Hopen0.830.832026-04-260synthetic-biology-lineage-tracing
gap-synthetic-biologGap in Seattle Hub lineage tracing: Clinical Translation, Ethics, and Biosafety open0.830.832026-04-260synthetic-biology-lineage-tracing
gap-synthetic-biologGap in Seattle Hub lineage tracing: Molecular Recording and Cellular Memory Systopen0.820.822026-04-260synthetic-biology-lineage-tracing
gap-synthetic-biologGap in Seattle Hub lineage tracing: Perturb-seq Coupled to Lineage and Exposure open0.790.792026-04-260synthetic-biology-lineage-tracing
gap-synthetic-biologGap in Seattle Hub lineage tracing: Delivery Systems for Longitudinal In-vivo Ceopen0.820.822026-04-260synthetic-biology-lineage-tracing
gap-synthetic-biologGap in Seattle Hub lineage tracing: Mammalian Synthetic Gene Circuits and Logic open0.810.812026-04-260synthetic-biology-lineage-tracing
123
SciDEX — scidex.ai — Dashboard | Mission Control | Status | How it Works | GitHub