| gap-human-brain-cell | [landscape-gap] Glia Diversity & Subclassification: Disease-associated microglia | open | 0.76 | 0.78 | 2026-04-25 | 0 | | human-brain-cell-types |
| gap-human-brain-cell | [landscape-gap] Cell Type Connectivity & Electrophysiology: Human Patch-seq data | open | 0.82 | 0.84 | 2026-04-25 | 0 | | human-brain-cell-types |
| gap-human-brain-cell | [landscape-gap] Disease-Associated Cell Type Vulnerability: Causal direction bet | open | 0.76 | 0.79 | 2026-04-25 | 0 | | human-brain-cell-types |
| gap-human-brain-cell | [landscape-gap] Developmental Cell Type Trajectories: Continuous developmental a | open | 0.75 | 0.78 | 2026-04-25 | 0 | | human-brain-cell-types |
| gap-human-brain-cell | [landscape-gap] Epigenomic Cell Type Specification: Cell-type-specific cis-regul | open | 0.80 | 0.82 | 2026-04-25 | 0 | | human-brain-cell-types |
| gap-human-brain-cell | [landscape-frontier] GWAS & Genetic Cell Type Enrichment: Cell-type enrichment r | open | 0.51 | 0.55 | 2026-04-25 | 0 | | human-brain-cell-types |
| gap-human-brain-cell | [landscape-frontier] Cell Type Connectivity & Electrophysiology: Human Patch-seq | open | 0.52 | 0.55 | 2026-04-25 | 0 | | human-brain-cell-types |
| gap-human-brain-cell | [landscape-gap] Cross-Species Cell Type Conservation: No gold-standard metric fo | open | 0.74 | 0.77 | 2026-04-25 | 0 | | human-brain-cell-types |
| gap-human-brain-cell | [landscape-frontier] Organoid & In Vitro Cell Type Models: Organoid cell types d | open | 0.53 | 0.57 | 2026-04-25 | 0 | | human-brain-cell-types |
| gap-landscape-7318c9 | Mechanistic basis of traumatic brain injury as an Alzheimer's risk factor | proposed | 0.67 | 0.67 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-620d08 | Mechanistic understanding of neuroinflammatory pathways in Alzheimer's disease p | proposed | 0.70 | 0.70 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-26d6b4 | Optimal integration of immunomodulatory therapies with existing Alzheimer's trea | proposed | 0.64 | 0.64 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-1388f2 | Development and clinical validation of blood-based biomarkers for early Alzheime | proposed | 0.71 | 0.71 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-64d8c5 | Scalable technology-enabled dementia care models for rural populations | proposed | 0.65 | 0.65 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-59c85e | Validated blood-based biomarkers for Alzheimer's disease screening in primary ca | proposed | 0.68 | 0.68 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-5184cb | Precision prevention trials targeting APOE4 homozygous carriers before symptom o | proposed | 0.70 | 0.70 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-5ebea5 | Culturally-adapted and diversity-inclusive dementia care intervention models | proposed | 0.64 | 0.64 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-1bb20b | Integrated mechanistic studies of traumatic brain injury as an AD risk factor | proposed | 0.67 | 0.67 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-ea6ca3 | Disease-modifying therapies targeting tau pathology beyond anti-amyloid approach | proposed | 0.65 | 0.65 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-8e3958 | What mechanistic questions remain unresolved beyond current work on Current unde | proposed | 0.52 | 0.52 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-ad8437 | What mechanistic questions remain unresolved beyond current work on Alzheimer's | proposed | 0.52 | 0.52 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-27624c | What mechanistic questions remain unresolved beyond current work on Pathogenesis | proposed | 0.52 | 0.52 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-3eb57a | What are the precise inflammatory signaling cascades linking microglial activati | proposed | 0.70 | 0.70 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-4c382d | What molecular mechanisms mediate the bidirectional risk between traumatic brain | proposed | 0.64 | 0.64 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-345cac | How can blood-based biomarkers be validated and implemented for widespread pre-s | proposed | 0.67 | 0.67 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-ebda70 | What combination strategies targeting multiple AD pathogenic pathways (Aβ, tau, | proposed | 0.67 | 0.67 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-79b248 | Why does the translational pipeline from AD animal models to human trials have s | proposed | 0.68 | 0.68 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-b95849 | How can precision medicine approaches stratify AD patients into mechanistically | proposed | 0.65 | 0.65 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-1f183b | Traumatic brain injury as a prodromal driver of Alzheimer's pathology: mechanist | proposed | 0.68 | 0.68 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-927fa8 | Fluid biomarker-guided monitoring in immunomodulatory Alzheimer's trials | proposed | 0.64 | 0.64 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-45059b | Combination therapy design: optimal sequencing of disease-modifying and supporti | proposed | 0.60 | 0.60 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-e7d1d4 | Integration of non-pharmacological dementia care models into rural healthcare sy | proposed | 0.62 | 0.62 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-269335 | Mechanistic basis of peripheral immune modulation in Alzheimer's disease neuroin | proposed | 0.65 | 0.65 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-5052d2 | Inflammatory endotypes and biomarker-guided patient stratification for anti-infl | proposed | 0.67 | 0.67 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-793f48 | Precision medicine subtypes beyond amyloid/tau for targeted therapeutic developm | proposed | 0.67 | 0.67 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-a95923 | Sex-specific neuroimmune mechanisms in Alzheimer's disease progression | proposed | 0.61 | 0.61 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-7a373d | Mechanistic basis of peripheral immune modulation in Alzheimer's disease neuroin | proposed | 0.68 | 0.68 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-ce2b3b | Mechanism-driven non-pharmacological interventions for rural and underserved AD | proposed | 0.62 | 0.62 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-24f95a | Mechanistic investigation of TBI-AD comorbidity in care model development | proposed | 0.64 | 0.64 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-762cc7 | Sex-differentiated inflammatory mechanisms in AD pathogenesis | proposed | 0.62 | 0.62 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-53f6fb | Temporal window specification for immunomodulatory intervention efficacy | proposed | 0.68 | 0.68 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-c70cb0 | Peripheral-to-central immune signal transduction across the blood-brain barrier | proposed | 0.67 | 0.67 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-bf109b | Traumatic brain injury as an AD accelerant: mechanistically undefined progressio | proposed | 0.66 | 0.66 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-c7d1d8 | Mechanistic pathway linking peripheral GM-CSF immunomodulation to CNS amyloid cl | proposed | 0.64 | 0.64 | 2026-04-25 | 0 | | alzheimers |
| gap-landscape-690e80 | How to integrate lineage recording with spatial transcriptomics? | proposed | 0.84 | 0.84 | 2026-04-25 | 0 | | synthetic-biology-lineage-tracing |
| gap-landscape-6254b2 | Gap in Human Brain Cell Types: Human Specific Chandelier Cell Molecular Identity | proposed | 0.64 | 0.64 | 2026-04-25 | 0 | | human-brain-cell-types |
| gap-landscape-3e14a6 | Gap in Human Brain Cell Types: Layer 5A Corticostriatal Neuron Selective Vulnera | proposed | 0.64 | 0.64 | 2026-04-25 | 0 | | human-brain-cell-types |
| gap-landscape-03c879 | Gap in Synthetic Biology Lineage Tracing: Epigenetic Memory Systems For Long Ter | proposed | 0.80 | 0.80 | 2026-04-25 | 0 | | synthetic-biology-lineage-tracing |
| gap-landscape-285f9d | Gap in Synthetic Biology Lineage Tracing: Logic Gates For Mammalian Synthetic Bi | proposed | 0.80 | 0.80 | 2026-04-25 | 0 | | synthetic-biology-lineage-tracing |
| gap-landscape-b2e871 | Gap in Human Brain Cell Types: Adult Prefrontal Cortex Neurogenesis Claims — Cur | proposed | 0.64 | 0.64 | 2026-04-25 | 0 | | human-brain-cell-types |