| h-ec228866 | Time-Dependent BBB Repair Strategy | 0.66 | 0.47 | MULTIPLE | proposed | 2026-04-16 | SDA-2026-04-16-gap-bbb-tjp-20260416041707 |
| h-7c93c300 | Parvalbumin Interneuron Vulnerability Links Lactate Transport to Gamma Oscillati | 0.66 | 0.62 | PVALB, SLC16A1/MCT1 | promoted | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-170325-196c7ee5 |
| h-782b40b1 | Optogenetic Microglial Deactivation via Engineered Inhibitory Opsins | 0.66 | 0.40 | CX3CR1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-691b42f1 |
| hyp_test_d2990401 | Test: TREM2 enhances amyloid clearance | 0.66 | 0.27 | TREM2 | proposed | 2026-04-17 | test-hypothesis-fixtures-v1 |
| h-89500d80 | Astrocyte-Microglia Communication Rebalancing via Cytokine Modulation | 0.66 | 0.70 | IL1A, TNF, C1Q | promoted | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222543-20260402 |
| h-19003961 | Arginine Methylation Enhancement Therapy | 0.65 | 0.60 | PRMT1 | debated | 2026-04-02 | sda-2026-04-01-gap-006 |
| h-76d375b520 | Gamma entrainment enhances TREM2-mediated microglial clearance of Aβ plaques via | 0.65 | 0.68 | TREM2 (triggering receptor expressed on myeloid cells 2); SY | proposed | 2026-04-28 | SRB-2026-04-28-h-bdbd2120 |
| h-af4b7555 | EPO Set Point Calibration Hypothesis | 0.65 | 0.50 | | proposed | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-155308-2c6815fb |
| h-e7e1f943 | Microbial Inflammasome Priming Prevention | 0.65 | 0.90 | NLRP3, CASP1, IL1B, PYCARD | proposed | 2026-04-02 | SDA-2026-04-01-gap-20260401-225155 |
| h-881362dc | KDM6A-Mediated H3K27me3 Rejuvenation | 0.65 | 0.40 | KDM6A | debated | 2026-04-02 | sda-2026-04-01-gap-v2-bc5f270e |
| h-ecacd219 | Nucleolar Stress Response Normalization | 0.65 | 0.50 | NPM1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-68d9c9c1 |
| h-e3e8407c | The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction | 0.65 | 0.50 | TFEB | proposed | 2026-04-03 | SDA-2026-04-02-gap-v2-5d0e3052 |
| h-780cbb9e6f | Radiation drives pericyte senescence through lysosome acidification failure and | 0.65 | 0.61 | TFEB | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-193006-9525a13b-debate |
| h-fe472f00 | SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs Calcium Sensing and | 0.65 | 0.65 | SUMO1, SYT1, C1QA, C3 | promoted | 2026-04-17 | SDA-2026-04-16-gap-debate-20260411-065018-92a34465 |
| h-6f21f62a | Microbiota-Microglia Axis Modulation | 0.65 | 0.30 | Multiple | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-06cb8e75 | Oligodendrocyte White Matter Vulnerability | 0.65 | 0.50 | MOG | proposed | 2026-04-03 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-4118a57ecd | Gamma entrainment corrects AD-related clock gene dysregulation to normalize hipp | 0.65 | 0.60 | PER1/PER2 (circadian clock genes); ARNTL (BMAL1); CREBBP (CR | proposed | 2026-04-28 | SRB-2026-04-28-h-bdbd2120 |
| h-3be15ed2 | Astrocyte APOE4-Specific Lipid Metabolism Correction | 0.65 | 0.50 | APOE | proposed | 2026-04-14 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-48b29b62 | C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward Neurotoxic Loop | 0.65 | 0.55 | C3AR1, C3, NFKB1 | promoted | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04 |
| h-aa8b4952 | Mitochondrial Calcium Buffering Enhancement via MCU Modulation | 0.65 | 0.20 | MCU | debated | 2026-04-02 | sda-2026-04-01-gap-004 |
| h-analogy-555bbea9 | Microglial TBK1 Deficiency Triggers Senescence-Associated Secretory Phenotype in | 0.65 | 0.60 | TBK1 | active | 2026-04-28 | |
| h-analogy-7609ce00 | ISR/eIF2α~P Overflow Represses Synaptic Proteostasis in Cortical Neurons in TDP- | 0.65 | 0.65 | TARDBP (TDP-43) | active | 2026-04-28 | |
| h-analogy-b8828d7f | LRRK2 Haploinsufficiency Traps Microglia in Senescence-Like Pro-Inflammatory Sta | 0.65 | 0.60 | LRRK2 | active | 2026-04-28 | |
| h-analogy-f05e4d69 | Chronic ISR Activation Represses Axonal Protein Synthesis in Nigrostriatal Dopam | 0.65 | 0.60 | EIF2AK3 (PERK) | active | 2026-04-28 | |
| h-analogy-9e00d99e | TDP-43 Liquid-Liquid Phase Separation Dominance in Stress Granules Predisposes t | 0.65 | 0.60 | TARDBP | active | 2026-04-28 | |
| hyp-lyso-snca-20ec74 | SNCA Oligomers Sequester TFEB Phosphatases to Create a Phospho-TFEB Tipping Poin | 0.65 | 0.72 | TFEB | active | 2026-04-28 | |
| h-14f3d499ffab | Daytime orexin tone preserves synaptic plasticity in prodromal AD | 0.65 | 0.62 | HCRTR1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-184240-f72e77ae |
| h-gwas-plcg2-protect | Calibrated PLCG2 activation can reproduce the protective rs72824905 microglial s | 0.65 | 0.66 | PLCG2 | proposed | 2026-04-26 | |
| h-a0b246fc70da | Tau/MAP6 antagonism in neurodegeneration progression | 0.65 | 0.65 | MAP6 | proposed | 2026-04-26 | paper-39257379 |
| h-5bdd4e163c5a | Competition-based domain allocation | 0.65 | 0.65 | MAPT | proposed | 2026-04-26 | paper-40040809 |
| h-308757f973 | Physiological SCFAs may reduce alpha-synuclein burden primarily through a gut-fi | 0.65 | 0.63 | SNCA | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-18cce7b525 |
| h-e96015f9f9 | LDLR Ligand-Binding Domain A Fusion for Receptor-Mediated Transcytosis | 0.65 | 0.65 | LDLR (LDLR gene); ARH/DAB2 adaptor proteins | proposed | 2026-04-22 | SDA-2026-04-02-gap-bbb-antibody-transport |
| h-35cc314907 | NeuroD1-Mediated Astrocyte Reprogramming Attenuates Neuroinflammation Through Ep | 0.65 | 0.75 | NeuroD1/NF-kB | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-060512 |
| h-3816b7fad9 | Loss of Homeostatic Epigenetic Identity Reprograms Microglia to Dystrophic State | 0.65 | 0.65 | EZH2/DNMT1/DNMT3A/P2RY12/TMEM119 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e |
| h-27bb110d29 | Pharmacologically Boost AQP4X Readthrough to Restore Perivascular Clearance | 0.65 | 0.65 | AQP4, AQP4X | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-7e1dc0b2 |
| h-2e817a8759 | TNF-α/NF-κB Axis Upregulates P2RY12 in VSMCs | 0.65 | 0.68 | RELA (p65), IKBKB (IKKβ) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-a4d6154a |
| h-4a6072a29e | mTORC1 displacement from lysosomal surface enables calcineurin access to TFEB | 0.65 | 0.55 | mTOR/FRAP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-387cb0ba |
| h-64c36c7c | NRF2-KEAP1 Pathway Activation to Coordinate Multi-Layer Antioxidant Defense | 0.65 | 0.65 | NRF2 (NFE2L2), KEAP1 | proposed | 2026-04-17 | SDA-2026-04-16-gap-ferroptosis-als-d2fb6bf796ed |
| h-58e655ee | APOE-Mediated Synaptic Lipid Raft Stabilization | 0.65 | 0.50 | SPTLC1 | proposed | 2026-04-03 | sda-2026-04-01-gap-auto-fd6b1635d9 |
| h-b7fb180808 | Autophagic Flux Enhancement Synergizes With Chaperones to Clear High-Molecular-W | 0.65 | 0.70 | TFEB, LAMP2A, SQSTM1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062052-28cbc764 |
| h-c35493aa | Glial Glycocalyx Remodeling Therapy | 0.65 | 0.30 | HSPG2 | debated | 2026-04-02 | sda-2026-04-01-gap-005 |
| h-4ae1454184 | CX3CR1 Promoter Methylation Disrupts Neuron-Microglia Cross-Talk | 0.65 | 0.72 | CX3CR1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-b262f4c9d8 | p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle Cargo for Coordinat | 0.65 | 0.68 | SQSTM1/p62 (SQSTM1), ULK1/FIP200 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7 |
| h-var-9d0c0787a5 | APOE-TREM2 Ligand Availability Dysfunction in Neurodegeneration | 0.65 | 0.80 | APOE | promoted | 2026-04-17 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-var-71ac892791 | Age-Dependent TREM2 Signaling Disrupts Astrocyte-Microglia Communication Leading | 0.65 | 0.80 | TREM2 | proposed | 2026-04-17 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-var-33f643b43a | TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling in White Matter Neur | 0.65 | 0.80 | TREM2 | proposed | 2026-04-17 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| SDA-2026-04-16-hyp-a | Apoptosis-Senescence Decision Point Intervention | 0.65 | 0.48 | TP53,BAX,BAK1,CASP3 | proposed | 2026-04-16 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| h-88e23c4a | IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral Tolerance Through M | 0.65 | 0.58 | IL10, CSF1R, CD40 | promoted | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-142329-c1db787b |
| h-509dad7981 | ALS-Linked OPTN/TBK1 Mutations Impair Phosphorylation Cascade Required for Patho | 0.65 | 0.64 | OPTN, TBK1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041423-3a6aa4ab |
| h-ef5f2ec0 | CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic Target | 0.65 | 0.72 | CLU-APOE-TREM2 axis (LXR/RXR pathway) | promoted | 2026-04-15 | SDA-2026-04-14-gap-pubmed-20260410-193701-11582758 |