| h-de52344d | Circadian-Metabolic Microglial Reprogramming | 0.66 | 0.59 | CLOCK, BMAL1, PER2 | proposed | 2026-04-04 | SDA-2026-04-04-gap-neuroinflammation-microglial-20260404 |
| h-20db7feba4 | Chronic cGAS/STING Hyperactivation Drives Progressive Neurodegeneration Through | 0.66 | 0.65 | cGAS (CGAS) / STING (TMEM173) / IFNAR1/2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-fc60e018 |
| h-d7212534 | Epigenetic Priming Ketone Protocol | 0.66 | 0.60 | HDAC2/HDAC3 | proposed | 2026-04-16 | SDA-BIOMNI-GENE_REG-785b71fe |
| h-737c3be8 | PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Subsequent p53 Activat | 0.66 | 0.72 | PARP1 | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-090658-7651c1d2 |
| h_seaad_005 | Vascular mural cell degeneration precedes and exacerbates parenchymal pathology | 0.66 | 0.69 | PDGFRB | proposed | 2026-04-04 | SDA-2026-04-04-analysis_sea_ad_001 |
| h-49791706 | Biorhythmic Interference via Controlled Sleep Oscillations | 0.66 | 0.40 | GABRA1 | debated | 2026-04-02 | sda-2026-04-01-gap-009 |
| h-25193345a5 | Agonistic antibodies targeting TREM2 to shift microglia toward neuroprotective p | 0.66 | 0.75 | TREM2 | proposed | 2026-05-01 | SDA-2026-05-01-gap-test-20260425-224949 |
| h-0c78964fbd | Pharmacologic SARM1 blockade to prevent Wallerian degeneration after axotomy | 0.66 | 0.70 | SARM1 | proposed | 2026-05-01 | SDA-2026-05-01-gap-test-20260425-224949 |
| h-spark-b94e9126c05d | E2E direct hypothesis a980051375 | 0.66 | 0.50 | TREM2 | proposed | 2026-04-26 | |
| h-aa33c51749 | Clusterin (APOJ) Secretion Deficit | 0.66 | 0.65 | CLU (APOJ); VCP | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-170057-a2f72fd8-debate |
| h-immunity-03dc171e | SPP1+ DAM as Source of Autoimmunity in Neurodegeneration | 0.66 | 0.66 | SPP1, GALECTIN3, LGALS3, CXCR4 | open | 2026-04-24 | |
| h-ea85fbfb90 | Excitatory Neuron Synaptic Dysfunction and Mitochondrial Stress via MAPT (tau) | 0.66 | 0.75 | MAPT | proposed | 2026-04-22 | SDA-2026-04-02-gap-seaad-debate-v4 |
| h-8b0a41b274 | H6: miR-132/212 Cluster Silencing Disables Neuronal Chromatin Compaction and Sur | 0.66 | 0.71 | miR-132-3p, MeCP2, DNMT3A | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-120802 |
| h-e8b3b9f971 | BBB Integrity Loss Defines Absolute Therapeutic Window Closure | 0.66 | 0.62 | MMP-9, Claudin-5, PDGFRβ (pericyte coverage) | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062045-7a6cf14e |
| h-7619add3b8 | Axonal Transport Defect: C9orf72 hexanucleotide expansion impairs retrograde aut | 0.66 | 0.75 | C9orf72 | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062212-6777e5dd |
| SDA-2026-04-16-hyp-d | SASP Modulation Rather Than Cell Elimination | 0.66 | 0.71 | NFKB1,IL1B,BDNF | promoted | 2026-04-16 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| h-8ef10f60b8 | GDF15-GFRAL Axis as Systemic Autophagy-Senescence Integrator | 0.66 | 0.58 | GDF15, GFRAL, NTRK2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062101-724971bc |
| h-59dcb68e7d | TREM2-Independent Microglial Activation via CSF1R | 0.66 | 0.68 | CSF1R | proposed | 2026-04-28 | SDA-2026-04-28-gap-methodol-20260427-041425-9e73b245 |
| h-329b1a79 | Complement C1QA Inhibition Synergizes with PV Interneuron Modulation | 0.66 | 0.45 | C1QA, PVALB | proposed | 2026-04-13 | SDA-2026-04-13-gap-pubmed-20260410-145358-185db2c8 |
| h-c2c5916913 | Parthenolide reduces tonic ADORA2A signaling by lowering inflammatory extracellu | 0.66 | 0.58 | ADORA2A | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-193037-1dc5e03a-debate |
| h-81349dd293 | Astrocyte IL-1β as Paracrine Mediator of Microglial Complement Expression | 0.66 | 0.60 | IL1B; IL1R1; MYD88 | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062128-afe67892 |
| h-e6ffaba500 | Conserved 5' Terminal Stem-Loop in NORAD Enables ASO-Mediated Restoration of Gen | 0.66 | 0.72 | NORAD | proposed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075007-232fbf62 |
| h-69c9d059 | TREM2 Activation as an Amplification Node for R136S Protection | 0.66 | 0.50 | TREM2 | proposed | 2026-04-13 | SDA-2026-04-13-gap-pubmed-20260410-145358-185db2c8 |
| h-a90e2e89 | Temporal TET2-Mediated Hydroxymethylation Cycling | 0.66 | 0.70 | TET2 | debated | 2026-04-02 | SDA-2026-04-04-gap-epigenetic-reprog-b685190e |
| h-analogy-8eef2620 | Alpha-synuclein phosphorylation-dominated LLPS hijacks synaptic vesicle condensa | 0.66 | 0.65 | SNCA | active | 2026-04-28 | |
| h-1e2bd420 | Mitochondrial RNA Granule Rescue Pathway | 0.66 | 0.60 | SYNCRIP | debated | 2026-04-02 | sda-2026-04-01-gap-v2-68d9c9c1 |
| h-f6097da86f | Cyclophilin D (CypD) Displacement by Mitochondrial TDP-43 | 0.66 | 0.65 | PPID (Cyclophilin D) | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062141-739c7f1c |
| h-ec228866 | Time-Dependent BBB Repair Strategy | 0.66 | 0.47 | MULTIPLE | proposed | 2026-04-16 | SDA-2026-04-16-gap-bbb-tjp-20260416041707 |
| h-7c93c300 | Parvalbumin Interneuron Vulnerability Links Lactate Transport to Gamma Oscillati | 0.66 | 0.62 | PVALB, SLC16A1/MCT1 | promoted | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-170325-196c7ee5 |
| h-782b40b1 | Optogenetic Microglial Deactivation via Engineered Inhibitory Opsins | 0.66 | 0.40 | CX3CR1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-691b42f1 |
| hyp_test_d2990401 | Test: TREM2 enhances amyloid clearance | 0.66 | 0.27 | TREM2 | proposed | 2026-04-17 | test-hypothesis-fixtures-v1 |
| h-89500d80 | Astrocyte-Microglia Communication Rebalancing via Cytokine Modulation | 0.66 | 0.70 | IL1A, TNF, C1Q | promoted | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222543-20260402 |
| h-19003961 | Arginine Methylation Enhancement Therapy | 0.65 | 0.60 | PRMT1 | debated | 2026-04-02 | sda-2026-04-01-gap-006 |
| h-af4b7555 | EPO Set Point Calibration Hypothesis | 0.65 | 0.50 | | proposed | 2026-04-13 | SDA-2026-04-13-gap-pubmed-20260410-155308-2c6815fb |
| h-e7e1f943 | Microbial Inflammasome Priming Prevention | 0.65 | 0.90 | NLRP3, CASP1, IL1B, PYCARD | proposed | 2026-04-02 | SDA-2026-04-01-gap-20260401-225155 |
| h-881362dc | KDM6A-Mediated H3K27me3 Rejuvenation | 0.65 | 0.40 | KDM6A | debated | 2026-04-02 | sda-2026-04-01-gap-v2-bc5f270e |
| h-ecacd219 | Nucleolar Stress Response Normalization | 0.65 | 0.50 | NPM1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-68d9c9c1 |
| h-e3e8407c | The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction | 0.65 | 0.50 | TFEB | proposed | 2026-04-02 | SDA-2026-04-02-gap-v2-5d0e3052 |
| h-780cbb9e6f | Radiation drives pericyte senescence through lysosome acidification failure and | 0.65 | 0.61 | TFEB | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-193006-9525a13b-debate |
| h-fe472f00 | SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs Calcium Sensing and | 0.65 | 0.65 | SUMO1, SYT1, C1QA, C3 | promoted | 2026-04-16 | SDA-2026-04-16-gap-debate-20260411-065018-92a34465 |
| h-6f21f62a | Microbiota-Microglia Axis Modulation | 0.65 | 0.30 | Multiple | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-06cb8e75 | Oligodendrocyte White Matter Vulnerability | 0.65 | 0.50 | MOG | proposed | 2026-04-02 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-3be15ed2 | Astrocyte APOE4-Specific Lipid Metabolism Correction | 0.65 | 0.50 | APOE | proposed | 2026-04-13 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-48b29b62 | C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward Neurotoxic Loop | 0.65 | 0.55 | C3AR1, C3, NFKB1 | promoted | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04 |
| h-aa8b4952 | Mitochondrial Calcium Buffering Enhancement via MCU Modulation | 0.65 | 0.20 | MCU | debated | 2026-04-02 | sda-2026-04-01-gap-004 |
| h-e20b3e9911 | TREM2-dependent microglial lipid handling in Alzheimer's disease | 0.65 | 0.76 | TREM2; APOE; ABCA1 | proposed | 2026-04-30 | SDA-2026-04-30-gap-test-20260425-224949 |
| h-analogy-555bbea9 | Microglial TBK1 Deficiency Triggers Senescence-Associated Secretory Phenotype in | 0.65 | 0.60 | TBK1 | active | 2026-04-28 | |
| h-analogy-7609ce00 | ISR/eIF2α~P Overflow Represses Synaptic Proteostasis in Cortical Neurons in TDP- | 0.65 | 0.65 | TARDBP (TDP-43) | active | 2026-04-28 | |
| h-analogy-b8828d7f | LRRK2 Haploinsufficiency Traps Microglia in Senescence-Like Pro-Inflammatory Sta | 0.65 | 0.60 | LRRK2 | active | 2026-04-28 | |
| h-analogy-f05e4d69 | Chronic ISR Activation Represses Axonal Protein Synthesis in Nigrostriatal Dopam | 0.65 | 0.60 | EIF2AK3 (PERK) | active | 2026-04-28 | |