| h-analogy-9e00d99e | TDP-43 Liquid-Liquid Phase Separation Dominance in Stress Granules Predisposes t | 0.65 | 0.60 | TARDBP | active | 2026-04-28 | |
| hyp-lyso-snca-20ec74 | SNCA Oligomers Sequester TFEB Phosphatases to Create a Phospho-TFEB Tipping Poin | 0.65 | 0.72 | TFEB | active | 2026-04-27 | |
| h-14f3d499ffab | Daytime orexin tone preserves synaptic plasticity in prodromal AD | 0.65 | 0.62 | HCRTR1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-184240-f72e77ae |
| h-gwas-plcg2-protect | Calibrated PLCG2 activation can reproduce the protective rs72824905 microglial s | 0.65 | 0.66 | PLCG2 | proposed | 2026-04-26 | |
| h-a0b246fc70da | Tau/MAP6 antagonism in neurodegeneration progression | 0.65 | 0.65 | MAP6 | proposed | 2026-04-25 | |
| h-5bdd4e163c5a | Competition-based domain allocation | 0.65 | 0.65 | MAPT | proposed | 2026-04-25 | |
| h-308757f973 | Physiological SCFAs may reduce alpha-synuclein burden primarily through a gut-fi | 0.65 | 0.63 | SNCA | proposed | 2026-04-24 | SDA-2026-04-25-gapdebate-18cce7b525 |
| h-e96015f9f9 | LDLR Ligand-Binding Domain A Fusion for Receptor-Mediated Transcytosis | 0.65 | 0.65 | LDLR (LDLR gene); ARH/DAB2 adaptor proteins | proposed | 2026-04-22 | SDA-2026-04-02-gap-bbb-antibody-transport |
| h-35cc314907 | NeuroD1-Mediated Astrocyte Reprogramming Attenuates Neuroinflammation Through Ep | 0.65 | 0.75 | NeuroD1/NF-kB | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-060512 |
| h-3816b7fad9 | Loss of Homeostatic Epigenetic Identity Reprograms Microglia to Dystrophic State | 0.65 | 0.65 | EZH2/DNMT1/DNMT3A/P2RY12/TMEM119 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e |
| h-27bb110d29 | Pharmacologically Boost AQP4X Readthrough to Restore Perivascular Clearance | 0.65 | 0.65 | AQP4, AQP4X | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-7e1dc0b2 |
| h-2e817a8759 | TNF-α/NF-κB Axis Upregulates P2RY12 in VSMCs | 0.65 | 0.68 | RELA (p65), IKBKB (IKKβ) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-a4d6154a |
| h-4a6072a29e | mTORC1 displacement from lysosomal surface enables calcineurin access to TFEB | 0.65 | 0.55 | mTOR/FRAP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-387cb0ba |
| h-64c36c7c | NRF2-KEAP1 Pathway Activation to Coordinate Multi-Layer Antioxidant Defense | 0.65 | 0.65 | NRF2 (NFE2L2), KEAP1 | proposed | 2026-04-16 | SDA-2026-04-16-gap-ferroptosis-als-d2fb6bf796ed |
| h-58e655ee | APOE-Mediated Synaptic Lipid Raft Stabilization | 0.65 | 0.50 | SPTLC1 | proposed | 2026-04-02 | sda-2026-04-01-gap-auto-fd6b1635d9 |
| h-b7fb180808 | Autophagic Flux Enhancement Synergizes With Chaperones to Clear High-Molecular-W | 0.65 | 0.70 | TFEB, LAMP2A, SQSTM1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062052-28cbc764 |
| h-c35493aa | Glial Glycocalyx Remodeling Therapy | 0.65 | 0.30 | HSPG2 | debated | 2026-04-02 | sda-2026-04-01-gap-005 |
| h-4ae1454184 | CX3CR1 Promoter Methylation Disrupts Neuron-Microglia Cross-Talk | 0.65 | 0.72 | CX3CR1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-b262f4c9d8 | p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle Cargo for Coordinat | 0.65 | 0.68 | SQSTM1/p62 (SQSTM1), ULK1/FIP200 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7 |
| h-var-9d0c0787a5 | APOE-TREM2 Ligand Availability Dysfunction in Neurodegeneration | 0.65 | 0.80 | APOE | promoted | 2026-04-17 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-var-71ac892791 | Age-Dependent TREM2 Signaling Disrupts Astrocyte-Microglia Communication Leading | 0.65 | 0.80 | TREM2 | proposed | 2026-04-17 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-var-33f643b43a | TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling in White Matter Neur | 0.65 | 0.80 | TREM2 | proposed | 2026-04-17 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| SDA-2026-04-16-hyp-a | Apoptosis-Senescence Decision Point Intervention | 0.65 | 0.48 | TP53,BAX,BAK1,CASP3 | proposed | 2026-04-16 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| h-88e23c4a | IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral Tolerance Through M | 0.65 | 0.58 | IL10, CSF1R, CD40 | promoted | 2026-04-13 | SDA-2026-04-13-gap-pubmed-20260410-142329-c1db787b |
| h-509dad7981 | ALS-Linked OPTN/TBK1 Mutations Impair Phosphorylation Cascade Required for Patho | 0.65 | 0.64 | OPTN, TBK1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041423-3a6aa4ab |
| h-ef5f2ec0 | CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic Target | 0.65 | 0.72 | CLU-APOE-TREM2 axis (LXR/RXR pathway) | promoted | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-193701-11582758 |
| h-782e55f6 | DNMT1-Targeting Antisense Oligonucleotide Reset | 0.65 | 0.30 | DNMT1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-bc5f270e |
| h-d40d2659 | HCN1-Mediated Resonance Frequency Stabilization Therapy | 0.65 | 0.40 | HCN1 | debated | 2026-04-02 | sda-2026-04-01-gap-004 |
| h-13bbfdc5 | Mitochondrial SPM Synthesis Platform Engineering | 0.65 | 0.20 | ALOX5 | debated | 2026-04-02 | sda-2026-04-01-gap-014 |
| h-e5f1182b | Epigenetic Reprogramming of Microglial Memory | 0.65 | 0.60 | DNMT3A, HDAC1/2 | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-e37e76c0 | S100B as Active Pathogenic BBB-Disrupting Signal via RAGE/NF-κB/Claudin-5 Axis | 0.65 | 0.18 | S100B | proposed | 2026-04-26 | SDA-2026-04-26-gap-bbb-permeability-biomarker-20260426 |
| h-a1d97415 | Inflammatory State-Dependent Ketone Timing | 0.65 | 0.40 | IRAKM | proposed | 2026-04-16 | SDA-2026-04-03-gap-debate-20260403-222618-2709aad9 |
| h-57862f8a | Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancement | 0.65 | 0.20 | IDH2 | debated | 2026-04-02 | sda-2026-04-01-gap-004 |
| h-3e6ca50b2f | Activity-Dependent Synaptic Tagging via CREB-BDNF-TrkB Signaling | 0.65 | 0.52 | CREB1, BDNF, NTRK2 (TrkB) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9 |
| h-e3506e5a | Synthetic Biology Rewiring via Orthogonal Receptors | 0.65 | 0.50 | CNO | debated | 2026-04-02 | sda-2026-04-01-gap-009 |
| h-SDA-2026-04-26-gap | Endothelial miR-181c-5p Upregulation Drives Claudin-5 Repression and Paracellula | 0.65 | 0.43 | CLDN5 (Claudin-5) - regulated by miR-181c-5p | proposed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260426-011448-7c85f5dc |
| h-SDA-2026-04-26-gap | Dominant-Negative Spliceosome Titration | 0.65 | 0.43 | U2AF2, SF3B1, PRPF8; splicing snRNPs | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260412-094853-199f4f1b |
| h-a3580b22 | Retromer-dependent retrograde endosomal signaling compartmentalization as biomar | 0.65 | 0.62 | VPS35, VPS26, VPS29 (retromer complex); TrkB/NTRK2 (cargo re | proposed | 2026-04-26 | SDA-2026-04-10-gap-debate-20260410-075000-7396040a |
| h-e6437136 | Ephrin-B2/EphB4 Axis Manipulation | 0.64 | 0.20 | EPHB4 | debated | 2026-04-02 | sda-2026-04-01-gap-005 |
| h-e003a35e | Oligodendrocyte Remyelination Enhancement | 0.64 | 0.60 | TREM2 | proposed | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-e714137dd7 | MCU Calcium Overload via MFN2/GRP75/VDAC1 MAM Dysfunction | 0.64 | 0.62 | MFN2, GRP75 (HSPA9), MCU (MICU1/2) | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062141-739c7f1c |
| h-699c0d72 | Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotective Strategy | 0.64 | 0.75 | | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-075356-20920528 |
| h-cb1d193197 | Microglial Metabolic Trained Immunity via mTOR-HIF1α Axis | 0.64 | 0.70 | MTOR/HIF1α | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-8efcb4cf | H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to A | 0.64 | 0.52 | TREM2 | proposed | 2026-04-14 | SDA-2026-04-26-trem2-showcase |
| h-245c3e93 | White Matter Immune Checkpoint Restoration | 0.64 | 0.30 | CXCL10 | proposed | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-8dc75e4072 | HDAC2 Phospho-Lock Window for Synaptic Gene Silencing | 0.64 | 0.72 | HDAC2 (phospho-S421) | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062039-7ef9980b |
| h-67d4435cb5 | Epigenetic Silencing of AIF1 Gene Locus by Chronic Inflammation | 0.64 | 0.55 | DNMT1/DNMT3A | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb |
| h-b34120a1 | Cell-Type Specific Metabolic Reprogramming | 0.64 | 0.30 | PPARA | proposed | 2026-04-13 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-ed23619c | HDAC6 Selective Inhibition to Restore Acetylation Balance and Microtubule Stabil | 0.64 | 0.68 | HDAC6 | promoted | 2026-04-13 | SDA-2026-04-13-gap-debate-20260412-094556-86f36bb3 |
| h-var-ac50d1e3d1 | SASP-Driven Microglial Metabolic Reprogramming in Synaptic Phagocytosis | 0.64 | 0.65 | HK2/PFKFB3 | proposed | 2026-04-07 | sda-2026-04-01-gap-013 |