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Hypotheses

2,369 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
hyp-SDA-2026-04-08-gADCY8-PKA-CREB Spatial Memory Enhancement0.460.50ADCY8active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062218-580b17ef
hyp-SDA-2026-04-08-gRibosomal Stress Response Exploitation0.460.50LTN1active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3
hyp-SDA-2026-04-08-gCytoskeletal Transport Selectivity Enhancement0.460.50KIF5Aactive2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3
hyp-SDA-2026-04-08-gMembrane Lipid Composition Therapeutic Modulation0.460.50HMGCRactive2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3
hyp-SDA-2026-04-08-gPhase Separation Modulation Therapy0.460.50FUSactive2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3
hyp-SDA-2026-04-08-gChaperone Network Reprogramming Therapy0.460.50HSPA1Aactive2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3
hyp-SDA-2026-04-08-gMitochondrial Proteostasis Coupling Therapy0.460.50ATF5active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3
hyp-SDA-2026-04-08-gLysosomal pH Gradient Manipulation0.460.50ATP6V1Aactive2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3
hyp-SDA-2026-04-08-gDual SPI1 Inhibition for Atherosclerosis-Neurodegeneration Axis0.460.50SPI1active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062122-bfac06c8
hyp-SDA-2026-04-08-gEpigenetic SPI1 Reprogramming Therapy0.460.50SPI1active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062122-bfac06c8
hyp-SDA-2026-04-08-gSPI1-C1Q Transcriptional Circuit Drives Cerebrovascular Neuroinflammation0.460.50SPI1active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062122-bfac06c8
hyp-SDA-2026-04-08-gNeurovascular Unit SPI1 Signaling Hub0.460.50SPI1active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062122-bfac06c8
hyp-SDA-2026-04-08-gMicroglial SPI1 Priming by Circulating C1Q0.460.50C1Qactive2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062122-bfac06c8
hyp-SDA-2026-04-08-gTemporal SPI1 Inhibition for Neuroplasticity Recovery0.460.50SPI1active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062122-bfac06c8
hyp-SDA-2026-04-08-gSPI1-Mediated Metabolic Reprogramming in Neuroinflammation0.460.50SPI1active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062122-bfac06c8
hyp-SDA-2026-04-08-gOligodendrocyte Stress Response Uniformity0.460.50EIF2AK3active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062111-db808ee9
hyp-SDA-2026-04-08-gIron Dysregulation as Convergent Pathomechanism0.460.50GPX4active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062111-db808ee9
hyp-SDA-2026-04-08-gSpinal Cord Microglia Activation State Convergence0.460.50CX3CR1active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062111-db808ee9
hyp-SDA-2026-04-08-gSpinal Cord Astrocyte Reactivity Convergence0.460.50STAT3active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062111-db808ee9
hyp-SDA-2026-04-08-gSpinal Vascular Unit Breakdown as Universal Driver0.460.50VEGFAactive2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062111-db808ee9
hyp-SDA-2026-04-08-gSphingosine-1-Phosphate Gradient Disruption0.460.50S1PR1active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062111-db808ee9
hyp-SDA-2026-04-08-gComplement Cascade as Final Common Effector0.460.50C5AR1active2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062111-db808ee9
hyp-SDA-2026-04-08-gGlymphatic System Disruption0.460.50AQP4active2026-04-28SDA-2026-04-08-gap-debate-20260406-062045-ce866189
hyp-SDA-2026-04-08-gTemporal Window Specificity0.460.50TNFactive2026-04-28SDA-2026-04-08-gap-debate-20260406-062045-ce866189
hyp-SDA-2026-04-08-gCNS-Peripheral Cytokine Compartmentalization0.460.50LRP1active2026-04-28SDA-2026-04-08-gap-debate-20260406-062045-ce866189
hyp-SDA-2026-04-08-gAstrocyte-Neuron Metabolic Coupling0.460.50SLC16A7active2026-04-28SDA-2026-04-08-gap-debate-20260406-062045-ce866189
hyp-SDA-2026-04-08-gMicroglial State-Dependent Cytokine Function0.460.50TREM2active2026-04-28SDA-2026-04-08-gap-debate-20260406-062045-ce866189
hyp-SDA-2026-04-08-gSynaptic Plasticity Preservation0.460.50TNFRSF1Bactive2026-04-28SDA-2026-04-08-gap-debate-20260406-062045-ce866189
hyp-SDA-2026-04-08-gCompensatory Cytokine Network Activation0.460.50NLRP3active2026-04-28SDA-2026-04-08-gap-debate-20260406-062045-ce866189
hyp-SDA-2026-04-08-gSphingolipid Metabolism Rebalancing0.460.50SMPD1active2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-fecb8755
hyp-SDA-2026-04-08-gLactate Shuttle Pathway Enhancement0.460.50SLC16A1active2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-fecb8755
hyp-SDA-2026-04-08-gMitochondrial Contact Site Stabilization0.460.50VDAC1active2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-fecb8755
hyp-SDA-2026-04-08-gPurinergic-Metabolic Coupling Restoration0.460.50P2RY12active2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-fecb8755
hyp-SDA-2026-04-08-gLipid Droplet Dynamics as Therapeutic Lever0.460.50DGAT1active2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-fecb8755
hyp-SDA-2026-04-08-gMetabolic Checkpoint Reprogramming via TREM2-mTOR Axis0.460.50MTORactive2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-fecb8755
hyp-SDA-2026-04-08-gNAD+ Salvage Pathway Optimization0.460.50NAMPTactive2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-fecb8755
hyp-SDA-2026-04-08-gLight-Independent Chronopharmacology0.460.50CSNK1D/CSNK1Eactive2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-16eccec1
hyp-SDA-2026-04-08-gMicroglial-Specific Circadian Gene Therapy0.460.50ARNTLactive2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-16eccec1
hyp-SDA-2026-04-08-gClock Gene-Mediated Microglial Reprogramming0.460.50ARNTL/CLOCKactive2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-16eccec1
hyp-SDA-2026-04-08-gCircadian Extracellular Matrix Remodeling0.460.50MMP9/HAS2active2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-16eccec1
hyp-SDA-2026-04-08-gREV-ERB Agonist Microglial Deactivation0.460.50NR1D1/NR1D2active2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-16eccec1
hyp-SDA-2026-04-08-gCircadian Metabolic Reprogramming Therapy0.460.50SIRT1/PRKAA1/PPARGC1Aactive2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-16eccec1
hyp-SDA-2026-04-08-gTemporal Cytokine Receptor Modulation0.460.50IL1R1/TNFRSF1Aactive2026-04-28SDA-2026-04-08-gap-debate-20260406-062033-16eccec1
hyp-SDA-2026-04-04-fSynaptic Vesicle Protein Phosphorylation Reprograms Release Probability and Inte0.460.50SYN1 (Synapsin-1)active2026-04-28SDA-2026-04-04-frontier-proteomics-1c3dba72
hyp-SDA-2026-04-04-fSynaptic Mitochondrial Proteostasis Collapse Disrupts ATP-Demand Coupling at Act0.460.50PPID (Cyclophilin D)active2026-04-28SDA-2026-04-04-frontier-proteomics-1c3dba72
hyp-SDA-2026-04-04-fCdk5/p25-PSD-95 Phosphorylation Disrupts Synaptic Scaffolding and Shifts APP Pro0.460.50PSD-95 (DLG4)active2026-04-28SDA-2026-04-04-frontier-proteomics-1c3dba72
hyp-sda-2026-04-01-gRNA Granule Phase Separation as Transient Cross-Seeding Hub0.460.50TARDBPactive2026-04-28sda-2026-04-01-gap-9137255b
hyp-sda-2026-04-01-gMembrane Lipid Composition-Dependent Specificity Switch Enabling Cross-Seeding R0.460.50PLD3active2026-04-28sda-2026-04-01-gap-9137255b
hyp-sda-2026-04-01-gGalectin-3 as Damage-Sensor Scaffold for Multimeric Cross-Seeding at Compromised0.460.50LGALS3active2026-04-28sda-2026-04-01-gap-9137255b
h-ae924ee8C1q Inhibition Prevents Synaptic Mitochondrial Dysfunction via Microglial-Neuron0.460.50C1QA/C1QB/C1QCproposed2026-04-15SDA-2026-04-15-gap-pubmed-20260411-082509-118fcb37
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