ID: hyp-SDA-2026-04-08-gap-pubmed-20260406-0
Hypothesis
Sphingosine-1-Phosphate Gradient Disruption
Convergent myelopathy phenotype results from disruption of S1P gradient that maintains immune cell trafficking and barrier function in spinal cord, with different etiologies converging by altering S1P metabolism.
EvidencePending (0%)📖 5 cit🗣 1 debates✓ 5 support✗ 2 oppose
✓ All Quality Gates Passed
🧪 Overview
Convergent myelopathy phenotype results from disruption of S1P gradient that maintains immune cell trafficking and barrier function in spinal cord, with different etiologies converging by altering S1P metabolism.
🧬 Mechanism
🔗 Mechanism from KG for S1PR1
Auto-built from this analysis's top knowledge-graph edges.
graph TD
Fingolimod["Fingolimod"] -->|associated with| S1PR1["S1PR1"]
siponimod["siponimod"] -->|associated with| S1PR1_1["S1PR1"]
S1PR1_2["S1PR1"] -->|controls| immune_cell_trafficking["immune cell trafficking"]
S1PR1_3["S1PR1"] -->|maintains| blood_spinal_cord_barrier["blood-spinal cord barrier"]
S1PR1_4["S1PR1"] -->|associated with| immune_cell_trafficking_5["immune cell trafficking"]
S1PR1_6["S1PR1"] -->|associated with| blood_brain_barrier["blood_brain_barrier"]
style Fingolimod fill:#4fc3f7,stroke:#333,color:#000
style S1PR1 fill:#4fc3f7,stroke:#333,color:#000
style siponimod fill:#4fc3f7,stroke:#333,color:#000
style S1PR1_1 fill:#4fc3f7,stroke:#333,color:#000
style S1PR1_2 fill:#ce93d8,stroke:#333,color:#000
style immune_cell_trafficking fill:#4fc3f7,stroke:#333,color:#000
style S1PR1_3 fill:#ce93d8,stroke:#333,color:#000
style blood_spinal_cord_barrier fill:#4fc3f7,stroke:#333,color:#000
style S1PR1_4 fill:#4fc3f7,stroke:#333,color:#000
style immune_cell_trafficking_5 fill:#4fc3f7,stroke:#333,color:#000
style S1PR1_6 fill:#4fc3f7,stroke:#333,color:#000
style blood_brain_barrier fill:#4fc3f7,stroke:#333,color:#000⚖️ Evidence
⚖️ Evidence Matrix5 supports0 contradicts
Supports
Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology.
Supports
Targeting Sphingosine-1-Phosphate Signaling in Immune-Mediated Diseases: Beyond Multiple Sclerosis.
Supports
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage.
Supports
Targeting the Sphingosine-1-Phosphate Pathway: New Opportunities in Inflammatory Bowel Disease Management.
Supports
Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment.
📖 Linked Papers
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — S1PR1
No curated PDB or AlphaFold mapping for S1PR1 yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for S1PR1.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
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📊 Market Indicators
7d Trend
↔
Stable
7d Momentum
▲ 0.0%
Volatility
High
0.0511
Events (7d)
0
Price History
▲5.2%💾 Resource Usage
LLM Tokens
12,040
$0.0722
Total Cost
$0.0722
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_synthesis
| source | v1_phase_c_backfill |
| origin_type | debate_synthesis |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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